2-(3-((5-methyl-1,3,4-oxadiazole-2-yl)methyl)phenyl)-N-(6-(4-(5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)ethanamide

Base Information

Chemical Name:2-(3-((5-methyl-1,3,4-oxadiazole-2-yl)methyl)phenyl)-N-(6-(4-(5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)ethanamide
CAS No.:1439399-40-2
Molecular Formula:C₃₀H₃₀N₈O₃S
Molecular Weight:582.686
Hs Code.:

Synonyms:2-(3-((5-methyl-1,3,4-oxadiazole-2-yl)methyl)phenyl)-N-(6-(4-(5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)ethanamide

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Chemical Property of 2-(3-((5-methyl-1,3,4-oxadiazole-2-yl)methyl)phenyl)-N-(6-(4-(5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)ethanamide

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Technology Process of 2-(3-((5-methyl-1,3,4-oxadiazole-2-yl)methyl)phenyl)-N-(6-(4-(5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)ethanamide

There total 11 articles about 2-(3-((5-methyl-1,3,4-oxadiazole-2-yl)methyl)phenyl)-N-(6-(4-(5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)ethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439394-45-2
N-(5-(4-(6-aminopyridazin-3-yl)butyl)-1,3,4-thiadiazol-2-yl)-2-phenylethanamide

: 1439400-34-6
2-(3-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)phenyl)acetic acid

: 1439399-40-2
2-(3-((5-methyl-1,3,4-oxadiazole-2-yl)methyl)phenyl)-N-(6-(4-(5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)ethanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 16h;

Reference yield:

: 19596-07-7
pent-4-ynenitrile

: 1439399-40-2
2-(3-((5-methyl-1,3,4-oxadiazole-2-yl)methyl)phenyl)-N-(6-(4-(5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)ethanamide

Guidance literature:: Multi-step reaction with 6 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 60 °C / Inert atmosphere

2: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol; ethyl acetate / 1 h

3: trifluoroacetic acid / 2 h / 65 °C

4: 1-methyl-pyrrolidin-2-one / 1.5 h / 0 °C

5: sodium hydroxide / methanol / 20 °C

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 10 wt% Pd(OH)2 on carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1439400-54-0
C₁₇H₁₄N₄O

: 1439399-40-2
2-(3-((5-methyl-1,3,4-oxadiazole-2-yl)methyl)phenyl)-N-(6-(4-(5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl)butyl)pyridazin-3-yl)ethanamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol; ethyl acetate / 1 h

2: trifluoroacetic acid / 2 h / 65 °C

3: 1-methyl-pyrrolidin-2-one / 1.5 h / 0 °C

4: sodium hydroxide / methanol / 20 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h

With 10 wt% Pd(OH)2 on carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;