2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylsulfinyl)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

Base Information

Chemical Name:2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylsulfinyl)-1H-pyrazol-3-yl)-1,3,4-oxadiazole
CAS No.:1219736-22-7
Molecular Formula:C₂₂H₁₉Cl₃N₄O₂S
Molecular Weight:509.843
Hs Code.:

Synonyms:2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylsulfinyl)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

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Chemical Property of 2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylsulfinyl)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

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Technology Process of 2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylsulfinyl)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

There total 8 articles about 2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylsulfinyl)-1H-pyrazol-3-yl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1219735-81-5
2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

: 1219736-22-7
2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylsulfinyl)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

Guidance literature:: 2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazol-3-yl)-1,3,4-oxadiazole; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 24437-53-4
1-(4-chlorophenyl)-2-methylthio ethanone

: 1219736-22-7
2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylsulfinyl)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tert-butyl methyl ether / 1.5 h / -40 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: ethanol / 17 h / 20 °C / Reflux

3.1: hydrazine hydrate / ethanol / 2 h / 90 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

5.1: Burgess Reagent / tetrahydrofuran / 0.83 h / 155 °C / Microwave irradiation

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C

With dmap; Burgess Reagent; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl methyl ether;

Reference yield:

: ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylsulfanyl-1H-pyrazole-3-carboxylate

: 1219736-22-7
2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylsulfinyl)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 2 h / 90 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

3: Burgess Reagent / tetrahydrofuran / 0.83 h / 155 °C / Microwave irradiation

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C

With dmap; Burgess Reagent; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane;