2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

Base Information

Chemical Name:2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazol-3-yl)-1,3,4-oxadiazole
CAS No.:1219735-81-5
Molecular Formula:C₂₂H₁₉Cl₃N₄OS
Molecular Weight:493.844
Hs Code.:

Synonyms:2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

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Chemical Property of 2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

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Technology Process of 2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

There total 7 articles about 2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazol-3-yl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1219737-04-8
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-N'-pivaloyl-1H-pyrazole-3-carbohydrazide

: 1219735-81-5
2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

Guidance literature:: With Burgess Reagent; In tetrahydrofuran; at 155 ℃; for 0.833333h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 815-17-8
trimethylpyruvic acid

: 1219735-81-5
2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

2: Burgess Reagent / tetrahydrofuran / 0.83 h / 155 °C / Microwave irradiation

With dmap; Burgess Reagent; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 24437-53-4
1-(4-chlorophenyl)-2-methylthio ethanone

: 1219735-81-5
2-tert-butyl-5-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazol-3-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tert-butyl methyl ether / 1.5 h / -40 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: ethanol / 17 h / 20 °C / Reflux

3.1: hydrazine hydrate / ethanol / 2 h / 90 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

5.1: Burgess Reagent / tetrahydrofuran / 0.83 h / 155 °C / Microwave irradiation

With dmap; Burgess Reagent; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl methyl ether;