2-methoxyethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

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Chemical Name:2-methoxyethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate
CAS No.:1361450-19-2
Molecular Formula:C₄₁H₆₄N₆O₇SSi₂
Molecular Weight:841.232
Hs Code.:

2-methoxyethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

Synonyms:2-methoxyethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

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Chemical Property of 2-methoxyethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

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Technology Process of 2-methoxyethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

There total 7 articles about 2-methoxyethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanone

: 1361450-19-2
2-methoxyethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / 2.5 h / -20 - 20 °C

2: N-iodo-succinimide / acetonitrile / 1 h / 20 °C

3: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C

4: N-Bromosuccinimide / acetonitrile / 0.5 h / 20 °C

5: aluminum oxide / N,N-dimethyl-formamide / 2 h / 100 - 130 °C

With aluminum oxide; potassium phosphate; N-Bromosuccinimide; N-iodo-succinimide; sodium hydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: C₁₃H₁₆N₄

: 1361450-19-2
2-methoxyethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 45 °C

2: 2,6-dimethylpyridine; sodium periodate / osmium(VIII) oxide / 1,4-dioxane; tert-butyl alcohol / 20 °C

3: sodium hydride / 2.5 h / -20 - 20 °C

4: N-iodo-succinimide / acetonitrile / 1 h / 20 °C

5: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C

6: N-Bromosuccinimide / acetonitrile / 0.5 h / 20 °C

7: aluminum oxide / N,N-dimethyl-formamide / 2 h / 100 - 130 °C

With 2,6-dimethylpyridine; aluminum oxide; potassium phosphate; sodium periodate; N-Bromosuccinimide; N-iodo-succinimide; sodium hydride; N-ethyl-N,N-diisopropylamine; osmium(VIII) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1361144-92-4
3-(4-methylenecyclohexyl)-3-oxopropanenitrile

: 1361450-19-2
2-methoxyethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: acetic acid / 100 °C / sealed tube

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 45 °C

3: 2,6-dimethylpyridine; sodium periodate / osmium(VIII) oxide / 1,4-dioxane; tert-butyl alcohol / 20 °C

4: sodium hydride / 2.5 h / -20 - 20 °C

5: N-iodo-succinimide / acetonitrile / 1 h / 20 °C

6: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C

7: N-Bromosuccinimide / acetonitrile / 0.5 h / 20 °C

8: aluminum oxide / N,N-dimethyl-formamide / 2 h / 100 - 130 °C

With 2,6-dimethylpyridine; aluminum oxide; potassium phosphate; sodium periodate; N-Bromosuccinimide; N-iodo-succinimide; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; osmium(VIII) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;