2-methoxyethyl 4-(7-amino-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

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Chemical Name:2-methoxyethyl 4-(7-amino-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate
CAS No.:1361450-20-5
Molecular Formula:C₂₉H₃₆N₆O₅S
Molecular Weight:580.708
Hs Code.:

Synonyms:2-methoxyethyl 4-(7-amino-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

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Chemical Property of 2-methoxyethyl 4-(7-amino-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

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Technology Process of 2-methoxyethyl 4-(7-amino-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

There total 9 articles about 2-methoxyethyl 4-(7-amino-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361450-19-2
2-methoxyethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

: 1361450-20-5
2-methoxyethyl 4-(7-amino-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

Guidance literature:: 2-methoxyethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate; With trifluoroacetic acid; In water; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanone

: 1361450-20-5
2-methoxyethyl 4-(7-amino-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / 2.5 h / -20 - 20 °C

2: N-iodo-succinimide / acetonitrile / 1 h / 20 °C

3: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C

4: N-Bromosuccinimide / acetonitrile / 0.5 h / 20 °C

5: aluminum oxide / N,N-dimethyl-formamide / 2 h / 100 - 130 °C

6: trifluoroacetic acid / water / 2 h / 20 °C

With aluminum oxide; potassium phosphate; N-Bromosuccinimide; N-iodo-succinimide; sodium hydride; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: C₁₃H₁₆N₄

: 1361450-20-5
2-methoxyethyl 4-(7-amino-6-(methylthio)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(2-methoxyethoxy)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 45 °C

2: 2,6-dimethylpyridine; sodium periodate / osmium(VIII) oxide / 1,4-dioxane; tert-butyl alcohol / 20 °C

3: sodium hydride / 2.5 h / -20 - 20 °C

4: N-iodo-succinimide / acetonitrile / 1 h / 20 °C

5: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C

6: N-Bromosuccinimide / acetonitrile / 0.5 h / 20 °C

7: aluminum oxide / N,N-dimethyl-formamide / 2 h / 100 - 130 °C

8: trifluoroacetic acid / water / 2 h / 20 °C

With 2,6-dimethylpyridine; aluminum oxide; potassium phosphate; sodium periodate; N-Bromosuccinimide; N-iodo-succinimide; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; osmium(VIII) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;