Technology Process of 4,6-difluoro-5-[4-(3-hydroxypropoxy)phenyl]-1H-indole-3-carboxylic acid
There total 11 articles about 4,6-difluoro-5-[4-(3-hydroxypropoxy)phenyl]-1H-indole-3-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium chlorite; sodium dihydrogen phosphate; 2-methyl-but-2-ene;
In
water; acetonitrile; tert-butyl alcohol;
at 0 - 20 ℃;
for 10h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere
3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 0.5 h / 20 - 90 °C
4: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate / water; acetonitrile; tert-butyl alcohol / 10 h / 0 - 20 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; sodium dihydrogen phosphate; 2-methyl-but-2-ene; potassium acetate; potassium carbonate;
In
1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetic acid; N-iodo-succinimide / 2 h / 20 °C
2.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 2.17 h / 20 °C
2.2: 88 h / 20 - 50 °C
3.1: copper(l) iodide / N,N-dimethyl-formamide / 3.75 h / 110 °C / Sealed tube
4.1: N-(chloromethylidene) N-methylmethanaminium; sodium hydroxide / water / 1 h / 20 °C
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 0.5 h / 20 - 90 °C
6.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate / water; acetonitrile; tert-butyl alcohol / 10 h / 0 - 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; N-iodo-succinimide; copper(l) iodide; sodium dihydrogen phosphate; 2-methyl-but-2-ene; N-(chloromethylidene) N-methylmethanaminium; potassium carbonate; acetic acid; triethylamine; sodium hydroxide;
In
water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;