4-(thiophen-3-yl)-N-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)benzamide

Base Information

Chemical Name:4-(thiophen-3-yl)-N-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)benzamide
CAS No.:1269797-53-6
Molecular Formula:C₂₇H₃₂FN₃O₂S
Molecular Weight:481.634
Hs Code.:

Synonyms:4-(thiophen-3-yl)-N-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(thiophen-3-yl)-N-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)benzamide

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Technology Process of 4-(thiophen-3-yl)-N-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)benzamide

There total 4 articles about 4-(thiophen-3-yl)-N-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 29886-64-4
4-(thiophen-3-yl)benzoic acid

: 1138217-76-1
4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butan-1-amine

: 1269797-53-6
4-(thiophen-3-yl)-N-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)benzamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm101323b

Reference yield:

: 1011-17-2
2-hydroxyphenylpiperazine

: 1269797-53-6
4-(thiophen-3-yl)-N-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 15 h / 20 °C

2: potassium carbonate / acetone / Reflux

3: hydrazine / ethanol / 5 h / Reflux

4: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

With potassium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; hydrazine; In ethanol; dichloromethane; acetone;
DOI:10.1021/jm101323b

Reference yield:

: 927187-08-4
2-{4-[4-(2-hydroxyphenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione

: 1269797-53-6
4-(thiophen-3-yl)-N-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / Reflux

2: hydrazine / ethanol / 5 h / Reflux

3: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

With potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; hydrazine; In ethanol; dichloromethane; acetone;
DOI:10.1021/jm101323b