(2R)-2-aminomethyl-2-benzylsulfanyl-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methanesulfonamide

Base Information

Chemical Name:(2R)-2-aminomethyl-2-benzylsulfanyl-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methanesulfonamide
CAS No.:1367740-29-1
Molecular Formula:C₂₄H₄₀N₂O₂S₂
Molecular Weight:452.726
Hs Code.:

Synonyms:(2R)-2-aminomethyl-2-benzylsulfanyl-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methanesulfonamide

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Chemical Property of (2R)-2-aminomethyl-2-benzylsulfanyl-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methanesulfonamide

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Technology Process of (2R)-2-aminomethyl-2-benzylsulfanyl-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methanesulfonamide

There total 5 articles about (2R)-2-aminomethyl-2-benzylsulfanyl-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1367740-26-8
(2R)-2-benzyl-sulfanyl-2-cyano-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methane-sulfonamide

: 1367740-29-1
(2R)-2-aminomethyl-2-benzylsulfanyl-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methanesulfonamide

Guidance literature:: (2R)-2-benzyl-sulfanyl-2-cyano-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methane-sulfonamide; With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 10h;

With water; sodium hydroxide; In diethyl ether;

Reference yield:

: 21286-54-4
Camphorsulfonyl chloride

: 1367740-29-1
(2R)-2-aminomethyl-2-benzylsulfanyl-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dmap / dichloromethane / 2 h / 50 °C

2.1: lithium methanolate / tetrahydrofuran / 0.17 h / 20 °C

2.2: 18 h / Reflux

3.1: sodium methylate / methanol / 0.5 h / 20 °C

3.2: 6 h / 20 °C

4.1: lithium aluminium tetrahydride / diethyl ether / 10 h / 20 °C

With lithium aluminium tetrahydride; lithium methanolate; sodium methylate; triethylamine; dmap; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;

Reference yield:

: 3144-16-9,61380-66-3
(1S)-10-camphorsulfonic acid

: 1367740-29-1
(2R)-2-aminomethyl-2-benzylsulfanyl-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine / dmap / dichloromethane / 2 h / 50 °C

3.1: lithium methanolate / tetrahydrofuran / 0.17 h / 20 °C

3.2: 18 h / Reflux

4.1: sodium methylate / methanol / 0.5 h / 20 °C

4.2: 6 h / 20 °C

5.1: lithium aluminium tetrahydride / diethyl ether / 10 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; lithium methanolate; sodium methylate; triethylamine; dmap; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;