(2R)-2-benzylsulfanyl-7,7-dimethyl-2-morpholin-4-yl-methyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methane-sulfonamide

Base Information

Chemical Name:(2R)-2-benzylsulfanyl-7,7-dimethyl-2-morpholin-4-yl-methyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methane-sulfonamide
CAS No.:1367740-30-4
Molecular Formula:C₂₈H₄₆N₂O₃S₂
Molecular Weight:522.817
Hs Code.:

Synonyms:(2R)-2-benzylsulfanyl-7,7-dimethyl-2-morpholin-4-yl-methyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methane-sulfonamide

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Chemical Property of (2R)-2-benzylsulfanyl-7,7-dimethyl-2-morpholin-4-yl-methyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methane-sulfonamide

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Technology Process of (2R)-2-benzylsulfanyl-7,7-dimethyl-2-morpholin-4-yl-methyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methane-sulfonamide

There total 6 articles about (2R)-2-benzylsulfanyl-7,7-dimethyl-2-morpholin-4-yl-methyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methane-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 5414-19-7
1,1'-oxybis(2-bromo-ethane)

: 1367740-29-1
(2R)-2-aminomethyl-2-benzylsulfanyl-7,7-dimethyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methanesulfonamide

: 1367740-30-4
(2R)-2-benzylsulfanyl-7,7-dimethyl-2-morpholin-4-yl-methyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methane-sulfonamide

Guidance literature:: With potassium carbonate; In acetonitrile; for 24h; Reflux;

Reference yield:

: 3144-16-9,61380-66-3
(1S)-10-camphorsulfonic acid

: 1367740-30-4
(2R)-2-benzylsulfanyl-7,7-dimethyl-2-morpholin-4-yl-methyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methane-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine / dmap / dichloromethane / 2 h / 50 °C

3.1: lithium methanolate / tetrahydrofuran / 0.17 h / 20 °C

3.2: 18 h / Reflux

4.1: sodium methylate / methanol / 0.5 h / 20 °C

4.2: 6 h / 20 °C

5.1: lithium aluminium tetrahydride / diethyl ether / 10 h / 20 °C

6.1: potassium carbonate / acetonitrile / 24 h / Reflux

With lithium aluminium tetrahydride; thionyl chloride; lithium methanolate; sodium methylate; potassium carbonate; triethylamine; dmap; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile;

Reference yield:

: 21286-54-4
Camphorsulfonyl chloride

: 1367740-30-4
(2R)-2-benzylsulfanyl-7,7-dimethyl-2-morpholin-4-yl-methyl-bicyclo[2.2.1]hept-1-yl-N,N-diisopropyl-methane-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dmap / dichloromethane / 2 h / 50 °C

2.1: lithium methanolate / tetrahydrofuran / 0.17 h / 20 °C

2.2: 18 h / Reflux

3.1: sodium methylate / methanol / 0.5 h / 20 °C

3.2: 6 h / 20 °C

4.1: lithium aluminium tetrahydride / diethyl ether / 10 h / 20 °C

5.1: potassium carbonate / acetonitrile / 24 h / Reflux

With lithium aluminium tetrahydride; lithium methanolate; sodium methylate; potassium carbonate; triethylamine; dmap; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile;