(3-fluoro-4-methylphenyl)(4-(6-isobutoxypyrimidin-4-yl)piperazin-1-yl)methanone

Base Information

Chemical Name:(3-fluoro-4-methylphenyl)(4-(6-isobutoxypyrimidin-4-yl)piperazin-1-yl)methanone
CAS No.:1359732-07-2
Molecular Formula:C₂₀H₂₅FN₄O₂
Molecular Weight:372.443
Hs Code.:

Synonyms:(3-fluoro-4-methylphenyl)(4-(6-isobutoxypyrimidin-4-yl)piperazin-1-yl)methanone

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Chemical Property of (3-fluoro-4-methylphenyl)(4-(6-isobutoxypyrimidin-4-yl)piperazin-1-yl)methanone

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Technology Process of (3-fluoro-4-methylphenyl)(4-(6-isobutoxypyrimidin-4-yl)piperazin-1-yl)methanone

There total 4 articles about (3-fluoro-4-methylphenyl)(4-(6-isobutoxypyrimidin-4-yl)piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 78-83-1
2-methyl-propan-1-ol

: 1359734-96-5
(4-(6-chloropyrimidin-4-yl)piperazin-1-yl)(3-fluoro-4-methylphenyl)methanone

: 1359732-07-2
(3-fluoro-4-methylphenyl)(4-(6-isobutoxypyrimidin-4-yl)piperazin-1-yl)methanone

Guidance literature:: 2-methyl-propan-1-ol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h;

(4-(6-chloropyrimidin-4-yl)piperazin-1-yl)(3-fluoro-4-methylphenyl)methanone; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 12h;

Reference yield:

: 350-28-7
3-fluoro-4-methyl-benzoic acid

: 1359732-07-2
(3-fluoro-4-methylphenyl)(4-(6-isobutoxypyrimidin-4-yl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / acetonitrile / 1 h / 20 °C

2.1: hydrogenchloride / ethyl acetate / 20 h / 20 °C

3.1: triethylamine / 1,4-dioxane / 4 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

4.2: 12 h / 20 °C

With hydrogenchloride; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1359734-95-4
tert-butyl 4-(3-fluoro-4-methylbenzoyl)piperazine-1-carboxylate

: 1359732-07-2
(3-fluoro-4-methylphenyl)(4-(6-isobutoxypyrimidin-4-yl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethyl acetate / 20 h / 20 °C

2.1: triethylamine / 1,4-dioxane / 4 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

3.2: 12 h / 20 °C

With hydrogenchloride; sodium hydride; triethylamine; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;