N-cyclopropyl-4-methyl-3-[3-{[(1R,2S)-2-methyl-3-(morpholin-4-yl)-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]benzamide

Base Information

Chemical Name:N-cyclopropyl-4-methyl-3-[3-{[(1R,2S)-2-methyl-3-(morpholin-4-yl)-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]benzamide
CAS No.:1095003-53-4
Molecular Formula:C₂₉H₃₅N₅O₃
Molecular Weight:501.629
Hs Code.:

Synonyms:N-cyclopropyl-4-methyl-3-[3-{[(1R,2S)-2-methyl-3-(morpholin-4-yl)-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]benzamide

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Chemical Property of N-cyclopropyl-4-methyl-3-[3-{[(1R,2S)-2-methyl-3-(morpholin-4-yl)-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]benzamide

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Technology Process of N-cyclopropyl-4-methyl-3-[3-{[(1R,2S)-2-methyl-3-(morpholin-4-yl)-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]benzamide

There total 10 articles about N-cyclopropyl-4-methyl-3-[3-{[(1R,2S)-2-methyl-3-(morpholin-4-yl)-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1095006-95-3
N-cyclopropyl-4-methyl-3-(3-((1R,2R)-2-methyl-3-oxo-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)benzamide

: 1095003-53-4
N-cyclopropyl-4-methyl-3-[3-{[(1R,2S)-2-methyl-3-(morpholin-4-yl)-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]benzamide

Guidance literature:: morpholine; N-cyclopropyl-4-methyl-3-(3-((1R,2R)-2-methyl-3-oxo-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)benzamide; With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 17h;

With water; sodium hydrogencarbonate; In dichloromethane; for 0.25h;

Reference yield:

: 1095005-58-5
methyl 3-[(cyanomethyl)amino]-4-methylbenzoate

: 1095003-53-4
N-cyclopropyl-4-methyl-3-[3-{[(1R,2S)-2-methyl-3-(morpholin-4-yl)-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,2-dichloro-benzene / 4 h / 100 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 50 °C

3.1: ammonium formate; N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethanol / 2 h / 70 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / 0 °C

5.1: Dess-Martin periodane / dichloromethane / 0.5 h / 25 °C

5.2: 0.25 h

6.1: sodium tris(acetoxy)borohydride / dichloromethane / 17 h / 20 °C

6.2: 0.25 h

With isopropylmagnesium chloride; ammonium formate; sodium tris(acetoxy)borohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-benzene;

Reference yield:

: 1095005-59-6
methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate

: 1095003-53-4
N-cyclopropyl-4-methyl-3-[3-{[(1R,2S)-2-methyl-3-(morpholin-4-yl)-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 50 °C

2.1: ammonium formate; N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethanol / 2 h / 70 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / 0 °C

4.1: Dess-Martin periodane / dichloromethane / 0.5 h / 25 °C

4.2: 0.25 h

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 17 h / 20 °C

5.2: 0.25 h

With isopropylmagnesium chloride; ammonium formate; sodium tris(acetoxy)borohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;