N-cyclopropyl-4-methyl-3-(3-((1R,2R)-2-methyl-3-oxo-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)benzamide

Base Information

Chemical Name:N-cyclopropyl-4-methyl-3-(3-((1R,2R)-2-methyl-3-oxo-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)benzamide
CAS No.:1095006-95-3
Molecular Formula:C₂₅H₂₆N₄O₃
Molecular Weight:430.506
Hs Code.:

Synonyms:N-cyclopropyl-4-methyl-3-(3-((1R,2R)-2-methyl-3-oxo-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)benzamide

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Chemical Property of N-cyclopropyl-4-methyl-3-(3-((1R,2R)-2-methyl-3-oxo-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)benzamide

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Technology Process of N-cyclopropyl-4-methyl-3-(3-((1R,2R)-2-methyl-3-oxo-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)benzamide

There total 9 articles about N-cyclopropyl-4-methyl-3-(3-((1R,2R)-2-methyl-3-oxo-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095003-51-2
N-cyclopropyl-3-[3-{[(1R,2R)-3-hydroxy-2-methyl-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide

: 1095006-95-3
N-cyclopropyl-4-methyl-3-(3-((1R,2R)-2-methyl-3-oxo-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)benzamide

Guidance literature:: N-cyclopropyl-3-[3-{[(1R,2R)-3-hydroxy-2-methyl-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]-4-methylbenzamide; With Dess-Martin periodane; In dichloromethane; at 25 ℃; for 0.5h;

With water; sodium hydrogencarbonate; sodium thiosulfate; In dichloromethane; for 0.25h;

Reference yield:

: 1095005-58-5
methyl 3-[(cyanomethyl)amino]-4-methylbenzoate

: 1095006-95-3
N-cyclopropyl-4-methyl-3-(3-((1R,2R)-2-methyl-3-oxo-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,2-dichloro-benzene / 4 h / 100 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 50 °C

3.1: ammonium formate; N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethanol / 2 h / 70 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / 0 °C

5.1: Dess-Martin periodane / dichloromethane / 0.5 h / 25 °C

5.2: 0.25 h

With isopropylmagnesium chloride; ammonium formate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-benzene;

Reference yield:

: 1095005-59-6
methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate

: 1095006-95-3
N-cyclopropyl-4-methyl-3-(3-((1R,2R)-2-methyl-3-oxo-1-phenylpropylamino)-2-oxopyrazin-1(2H)-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 50 °C

2.1: ammonium formate; N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethanol / 2 h / 70 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / 0 °C

4.1: Dess-Martin periodane / dichloromethane / 0.5 h / 25 °C

4.2: 0.25 h

With isopropylmagnesium chloride; ammonium formate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;