4-{N-[(6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid

Base Information

Chemical Name:4-{N-[(6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid
CAS No.:157701-39-8
Molecular Formula:C₂₂H₁₉N₃O₃
Molecular Weight:373.411
Hs Code.:

Synonyms:4-{N-[(6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid

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Chemical Property of 4-{N-[(6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid

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Technology Process of 4-{N-[(6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid

There total 14 articles about 4-{N-[(6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 157701-04-7
N-(4-{N-[(6RS)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoyl)-L-glutamic acid

: 174487-71-9
4-{N-[(6R/6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid

: 157701-39-8
4-{N-[(6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid

: 157701-05-8
N-(4-{N-[(6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoyl)-L-glutamic acid

Guidance literature:: With water; tris hydrochloride; zinc(II) chloride; carboxypeptidase G₂; In water; at 37 ℃; for 10h; pH=7.3; Enzymatic reaction;

Reference yield: 80.0%

: 157701-05-8
N-(4-{N-[(6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoyl)-L-glutamic acid

: 157701-39-8
4-{N-[(6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid

Guidance literature:: With water; tris hydrochloride; zinc(II) chloride; carboxypeptidase G₂; at 37 ℃; for 72h; pH=7.3;

Reference yield:

: 157701-34-3
5-acetamido-6-cyanoindane

: 157701-39-8
4-{N-[(6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: 83 percent / H₂O₂ / aq. ethanol / 1 h / 50 - 55 °C

2.1: t-BuOK / dimethylsulfoxide / 0.5 h / 20 °C

2.2: 51 percent / dimethylsulfoxide / 24 h

3.1: 37 percent / tert-butyl hydroperoxide; CrO₃; H₂O / CH₂Cl₂ / 22 h / 20 °C

4.1: TsOH*H₂O; 3 Angstroem molecular sieves / 1,2-dimethoxy-ethane / 4 h / Heating

5.1: NaBH₃CN; CH₃COOH / methanol; 1,2-dimethoxy-ethane / 17 h / 20 °C

6.1: 77 percent / CaCO₃ / N,N-dimethyl-acetamide / 21 h / 98 - 105 °C

7.1: 93 percent / NaOH; H₂O / methanol / 24 h / 20 °C

8.1: trisHCl; ZnCl₂; H₂O / carboxypeptidase G₂ / H₂O / 10 h / 37 °C / pH 7.3 / Enzymatic reaction

With chromium(VI) oxide; tert.-butylhydroperoxide; sodium hydroxide; 3 A molecular sieve; potassium tert-butylate; water; dihydrogen peroxide; tris hydrochloride; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; calcium carbonate; zinc(II) chloride; carboxypeptidase G₂; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; 1.1: Cyclization / 2.1: Metallation / 2.2: Alkylation / 3.1: Oxidation / 4.1: Condensation / 5.1: Reduction / 6.1: Alkylation / 7.1: Hydrolysis / 8.1: Hydrolysis;