{3,5-bis-[4-(tert-butoxycarbonylamino-methyl)-benzylcarbamoyl]-phenyl}-carbamic acid hexadec-2-enyl ester

Base Information

Chemical Name:{3,5-bis-[4-(tert-butoxycarbonylamino-methyl)-benzylcarbamoyl]-phenyl}-carbamic acid hexadec-2-enyl ester
CAS No.:867067-84-3
Molecular Formula:C₅₁H₇₃N₅O₈
Molecular Weight:884.169
Hs Code.:

{3,5-bis-[4-(<i>tert</i>-butoxycarbonylamino-methyl)-benzylcarbamoyl]-phenyl}-carbamic acid hexadec-2-enyl ester

Synonyms:{3,5-bis-[4-(tert-butoxycarbonylamino-methyl)-benzylcarbamoyl]-phenyl}-carbamic acid hexadec-2-enyl ester

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Chemical Property of {3,5-bis-[4-(tert-butoxycarbonylamino-methyl)-benzylcarbamoyl]-phenyl}-carbamic acid hexadec-2-enyl ester

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Technology Process of {3,5-bis-[4-(tert-butoxycarbonylamino-methyl)-benzylcarbamoyl]-phenyl}-carbamic acid hexadec-2-enyl ester

There total 5 articles about {3,5-bis-[4-(tert-butoxycarbonylamino-methyl)-benzylcarbamoyl]-phenyl}-carbamic acid hexadec-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 867067-83-2
5-[((E)-Hexadec-2-enyl)oxycarbonylamino]-isophthalic acid

: 108468-00-4
tert-butyl 4-(aminomethyl)benzylcarbamate

: 867067-84-3
{3,5-bis-[4-(tert-butoxycarbonylamino-methyl)-benzylcarbamoyl]-phenyl}-carbamic acid hexadec-2-enyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1039/b506177f

Reference yield:

: 867067-81-0
2-allyloxycarbonylamino-isophthalic acid diethyl ester

: 867067-84-3
{3,5-bis-[4-(tert-butoxycarbonylamino-methyl)-benzylcarbamoyl]-phenyl}-carbamic acid hexadec-2-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / Grubbs 1-st generation catalyst / CH₂Cl₂ / 12 h / Heating

2: 100 percent / aq. LiOH / tetrahydrofuran; methanol / 10 h / 20 °C

3: 67 percent / benzotriazole-1-yl-oxy-trispropylidinophosphonium*PF₆; DIEA / dimethylformamide / 12 h / 20 °C

With lithium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b506177f

Reference yield:

: 99-31-0
5-aminoisophthalic acid

: 867067-84-3
{3,5-bis-[4-(tert-butoxycarbonylamino-methyl)-benzylcarbamoyl]-phenyl}-carbamic acid hexadec-2-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / 5 h / Heating

2: 81 percent / pyridine / 0 - 20 °C

3: 40 percent / Grubbs 1-st generation catalyst / CH₂Cl₂ / 12 h / Heating

4: 100 percent / aq. LiOH / tetrahydrofuran; methanol / 10 h / 20 °C

5: 67 percent / benzotriazole-1-yl-oxy-trispropylidinophosphonium*PF₆; DIEA / dimethylformamide / 12 h / 20 °C

With pyridine; lithium hydroxide; thionyl chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b506177f