Cbz-Gly-Thr(Ψ^Me,MePro)-Phe-Phe-Gly-OMe

Base Information

Chemical Name:Cbz-Gly-Thr(Ψ^Me,MePro)-Phe-Phe-Gly-OMe
CAS No.:871915-39-8
Molecular Formula:C₃₈H₄₅N₅O₉
Molecular Weight:715.803
Hs Code.:

Cbz-Gly-Thr(Ψ<sup>Me,Me</sup>Pro)-Phe-Phe-Gly-OMe

Synonyms:Cbz-Gly-Thr(Ψ^Me,MePro)-Phe-Phe-Gly-OMe

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Chemical Property of Cbz-Gly-Thr(Ψ^Me,MePro)-Phe-Phe-Gly-OMe

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Technology Process of Cbz-Gly-Thr(Ψ^Me,MePro)-Phe-Phe-Gly-OMe

There total 8 articles about Cbz-Gly-Thr(Ψ^Me,MePro)-Phe-Phe-Gly-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.5%

: 871915-38-7
Cbz-Gly-Thr(Ψ^Me,MePro)-OH

: 105224-80-4
H₂N-Phe-Phe-Gly-OMe

: 871915-39-8
Cbz-Gly-Thr(Ψ^Me,MePro)-Phe-Phe-Gly-OMe

Guidance literature:: With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 17h;
DOI:10.1021/ol0522891

Reference yield:

: 51165-32-3
Cbz-Phe-Phe-Gly-OMe

: 871915-39-8
Cbz-Gly-Thr(Ψ^Me,MePro)-Phe-Phe-Gly-OMe

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / methanol; tetrahydrofuran / 18 h

2: 81.5 percent / N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole monohydrate / dimethylformamide / 17 h / 20 °C

With 4-methyl-morpholine; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol0522891

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 871915-39-8
Cbz-Gly-Thr(Ψ^Me,MePro)-Phe-Phe-Gly-OMe

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-methylmorpholine; isobutyl chloroformate / CH₂Cl₂ / 0.05 h / -15 °C

1.2: 85 percent / diisopropylethylamine / CH₂Cl₂; dimethylformamide / 2 h / 20 °C

2.1: 98 percent / H₂ / Pd/C / methanol / 6 h

3.1: 76 percent / N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole / CH₂Cl₂; dimethylformamide / 18 h / 20 °C

4.1: 100 percent / H₂ / Pd/C / methanol; tetrahydrofuran / 18 h

5.1: 81.5 percent / N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole monohydrate / dimethylformamide / 17 h / 20 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0522891