(2R,3R,4S)-1-((R)-4-Benzyl-2-thioxo-thiazolidin-3-yl)-3-hydroxy-4-(4-methoxy-benzyloxy)-2-methyl-hept-6-en-1-one

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Chemical Name:(2R,3R,4S)-1-((R)-4-Benzyl-2-thioxo-thiazolidin-3-yl)-3-hydroxy-4-(4-methoxy-benzyloxy)-2-methyl-hept-6-en-1-one
CAS No.:911237-05-3
Molecular Formula:C₂₆H₃₁NO₄S₂
Molecular Weight:485.668
Hs Code.:

Synonyms:(2R,3R,4S)-1-((R)-4-Benzyl-2-thioxo-thiazolidin-3-yl)-3-hydroxy-4-(4-methoxy-benzyloxy)-2-methyl-hept-6-en-1-one

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Chemical Property of (2R,3R,4S)-1-((R)-4-Benzyl-2-thioxo-thiazolidin-3-yl)-3-hydroxy-4-(4-methoxy-benzyloxy)-2-methyl-hept-6-en-1-one

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Technology Process of (2R,3R,4S)-1-((R)-4-Benzyl-2-thioxo-thiazolidin-3-yl)-3-hydroxy-4-(4-methoxy-benzyloxy)-2-methyl-hept-6-en-1-one

There total 4 articles about (2R,3R,4S)-1-((R)-4-Benzyl-2-thioxo-thiazolidin-3-yl)-3-hydroxy-4-(4-methoxy-benzyloxy)-2-methyl-hept-6-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 863324-53-2
(R)-1-(4-benzyl-2-thioxothiazolidin-3-yl)propan-1-one

: 947619-70-7
(S)-2-(4-methoxybenzyloxy)pent-4-enal

: 911237-05-3
(2R,3R,4S)-1-((R)-4-Benzyl-2-thioxo-thiazolidin-3-yl)-3-hydroxy-4-(4-methoxy-benzyloxy)-2-methyl-hept-6-en-1-one

Guidance literature:: (R)-1-(4-benzyl-2-thioxothiazolidin-3-yl)propan-1-one; With 1-methyl-pyrrolidin-2-one; titanium tetrachloride; (-)-sparteine; In dichloromethane; at 0 ℃;

(S)-2-(4-methoxybenzyloxy)pent-4-enal; In dichloromethane; at -78 - -30 ℃;
DOI:10.1021/ol0615782

Reference yield:

: 911237-04-2
(2S)-2-(4-methoxybenzyloxy)-4-pentenol

: 911237-05-3
(2R,3R,4S)-1-((R)-4-Benzyl-2-thioxo-thiazolidin-3-yl)-3-hydroxy-4-(4-methoxy-benzyloxy)-2-methyl-hept-6-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: (COCl)2; DMSO / CH₂Cl₂ / 0.5 h / -78 - -65 °C

2.1: TiCl₄; (-)-sparteine; N-methylpyrrolidinone / CH₂Cl₂ / 0 °C

2.2: CH₂Cl₂ / -78 - -30 °C

With 1-methyl-pyrrolidin-2-one; oxalyl dichloride; titanium tetrachloride; dimethyl sulfoxide; (-)-sparteine; In dichloromethane; 1.1: Swern oxidation;
DOI:10.1021/ol0615782

Reference yield:

: 911237-03-1
(R)-4-Isopropyl-3-[(S)-2-(4-methoxy-benzyloxy)-pent-4-enoyl]-oxazolidin-2-one

: 911237-05-3
(2R,3R,4S)-1-((R)-4-Benzyl-2-thioxo-thiazolidin-3-yl)-3-hydroxy-4-(4-methoxy-benzyloxy)-2-methyl-hept-6-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 93 percent / LiBH₄ / diethyl ether; methanol / 2 h / 0 °C

2.1: (COCl)2; DMSO / CH₂Cl₂ / 0.5 h / -78 - -65 °C

3.1: TiCl₄; (-)-sparteine; N-methylpyrrolidinone / CH₂Cl₂ / 0 °C

3.2: CH₂Cl₂ / -78 - -30 °C

With 1-methyl-pyrrolidin-2-one; lithium borohydride; oxalyl dichloride; titanium tetrachloride; dimethyl sulfoxide; (-)-sparteine; In methanol; diethyl ether; dichloromethane; 2.1: Swern oxidation;
DOI:10.1021/ol0615782