1-[(4S)-4-(phenylMethyl)-2-thioxo-3-thiazolidinyl]-1-Propanone

Base Information

• Chemical Name: 1-[(4S)-4-(phenylMethyl)-2-thioxo-3-thiazolidinyl]-1-Propanone
• CAS No.: 863324-53-2
• Molecular Formula: C₁₃H₁₅NOS₂
• Molecular Weight: 265.4
• Mol file: 863324-53-2.mol

Synonyms:1-[(4S)-4-(phenylMethyl)-2-thioxo-3-thiazolidinyl]-1-Propanone

Chemical Property of 1-[(4S)-4-(phenylMethyl)-2-thioxo-3-thiazolidinyl]-1-Propanone

Chemical Property:

• PSA: 77.70000
• LogP: 2.80590

Purity/Quality:

98% ^*data from raw suppliers

1-Propanone,1-[(4R)-4-(phenylmethyl)-2-thioxo-3-thiazolidinyl]- 96% ^*data from reagent suppliers

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Technology Process of 1-[(4S)-4-(phenylMethyl)-2-thioxo-3-thiazolidinyl]-1-Propanone

There total 9 articles about 1-[(4S)-4-(phenylMethyl)-2-thioxo-3-thiazolidinyl]-1-Propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

propionyl chloride (79-03-8) + (S)-4-benzylthiazolidin-2-thione (171877-39-7) → (S)-3-propanoyl-4-benzyl-1,3-thiazolidine-2-thione (263764-23-4,863324-53-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 78 ℃; Inert atmosphere;

DOI:10.1080/10426507.2014.931399

Reference yield: 94.3%

propionic acid (802294-64-0,79-09-4) + (S)-4-benzylthiazolidin-2-thione (171877-39-7) → (S)-3-propanoyl-4-benzyl-1,3-thiazolidine-2-thione (263764-23-4,863324-53-2)

Guidance literature:

With 2-chloro-1-methylpyridinium p-toluenesulfonate; triethylamine; In dichloromethane; at 20 ℃; for 7h;

Reference yield: 88.0%

phenylacetic acid (103-82-2) + (S)-4-benzylthiazolidin-2-thione (171877-39-7) → (S)-3-propanoyl-4-benzyl-1,3-thiazolidine-2-thione (263764-23-4,863324-53-2)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1055/s-2003-42117

upstream raw materials:

propionyl chloride

(S)-4-benzylthiazolidin-2-thione

phenylacetic acid

L-Phenylalaninol

Downstream raw materials:

(4E)-1-[(4S)-4-benzyl-2-thioxo(1,3-thiazolidin-3-yl)](2S,3S)-3-hydroxy-methyl-5-phenylpent-4-en-1-one

(2S,3R,6S,7S,8S,9S,10S)-1-((R)-4-benzyl-2-thioxothiazolidin-3-yl)-11-(benzyloxy)-7-(tert-butyldimethylsilyloxy)-3-hydroxy-9-(4-methoxybenzyloxy)-2,6,8,10-tetramethylundecan-1-one

(2R,3R,4R)-1-((R)-4-benzyl-2-thioxothiazolidin-3-yl)-3-hydroxy-4-((4-methoxybenzyl)oxy)-2,6-dimethylhept-6-en-1-one

(2R,3R,E)-1-((R)-4-benzyl-2-thioxothiazolidin-3-yl)-3-hydroxy-2-methyl-5-phenylpent-4-en-1-one

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