methyl [7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetate

Base Information

Chemical Name:methyl [7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetate
CAS No.:1258855-72-9
Molecular Formula:C₂₅H₂₆N₄O₄
Molecular Weight:446.506
Hs Code.:

Synonyms:methyl [7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetate

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Chemical Property of methyl [7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetate

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Technology Process of methyl [7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetate

There total 7 articles about methyl [7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1167415-61-3
2-[(1-methylethyl)oxy]-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride

: 96-32-2
bromoacetic acid methyl ester

: 1258855-72-9
methyl [7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetate

Guidance literature:: With potassium carbonate; In acetonitirile; at 20 - 60 ℃; Inert atmosphere;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1258855-72-9
methyl [7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 4 h / 20 °C

2: pyridine / toluene / 1.5 h / 110 °C / Inert atmosphere; Reflux

3: hydrogenchloride / dichloromethane; 1,4-dioxane; diethyl ether / 3.5 h

4: potassium carbonate / acetonitirile / 20 - 60 °C / Inert atmosphere

With pyridine; hydrogenchloride; oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In 1,4-dioxane; acetonitirile; diethyl ether; dichloromethane; toluene;

Reference yield:

: 264264-28-0
1,1-dimethylethyl-7-{[(trifluoromethyl)sulfonyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 1258855-72-9
methyl [7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.25 h / 100 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 4 h / 60 °C / Reflux

3: pyridine / toluene / 1.5 h / 110 °C / Inert atmosphere; Reflux

4: hydrogenchloride / dichloromethane; 1,4-dioxane; diethyl ether / 3.5 h

5: potassium carbonate / acetonitirile / 20 - 60 °C / Inert atmosphere

With pyridine; hydrogenchloride; hydroxylamine hydrochloride; sodium hydrogencarbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; acetonitirile; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;