2-((S)-pyrrolidin-2-yl)-5-(4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazole

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Chemical Name:2-((S)-pyrrolidin-2-yl)-5-(4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazole
CAS No.:1307304-56-8
Molecular Formula:C₂₂H₂₈N₆
Molecular Weight:376.505
Hs Code.:

Synonyms:2-((S)-pyrrolidin-2-yl)-5-(4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazole

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Chemical Property of 2-((S)-pyrrolidin-2-yl)-5-(4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazole

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Technology Process of 2-((S)-pyrrolidin-2-yl)-5-(4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazole

There total 4 articles about 2-((S)-pyrrolidin-2-yl)-5-(4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1307304-55-7
(S)-tert-butyl 2-(5-(4-((2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1307304-56-8
2-((S)-pyrrolidin-2-yl)-5-(4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazole

Guidance literature:: (S)-tert-butyl 2-(5-(4-((2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

With ammonia; In methanol;

Reference yield:

: 1228968-41-9
2-[5-(4-ethynyl-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1307304-56-8
2-((S)-pyrrolidin-2-yl)-5-(4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 24 h / 90 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 7.5 h

3: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With copper(l) iodide; hydrogen; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1007882-04-3
(S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

: 1307304-56-8
2-((S)-pyrrolidin-2-yl)-5-(4-(2-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere; Sealed pressure tube

2: triethylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 24 h / 90 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / methanol / 7.5 h

4: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With copper(l) iodide; hydrogen; triethylamine; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;