(S)-tert-butyl 2-(5-(4-((2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Name:(S)-tert-butyl 2-(5-(4-((2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate
CAS No.:1307304-55-7
Molecular Formula:C₃₂H₄₄N₆O₄
Molecular Weight:576.739
Hs Code.:

Synonyms:(S)-tert-butyl 2-(5-(4-((2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 2-(5-(4-((2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Technology Process of (S)-tert-butyl 2-(5-(4-((2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

There total 3 articles about (S)-tert-butyl 2-(5-(4-((2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228964-45-1
(S)-tert-butyl 2-(5-(4-((2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethynyl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1307304-55-7
(S)-tert-butyl 2-(5-(4-((2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 7.5h;

Reference yield:

: 1228968-41-9
2-[5-(4-ethynyl-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1307304-55-7
(S)-tert-butyl 2-(5-(4-((2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 24 h / 90 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 7.5 h

With copper(l) iodide; hydrogen; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1007882-04-3
(S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

: 1307304-55-7
(S)-tert-butyl 2-(5-(4-((2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)ethyl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere; Sealed pressure tube

2: triethylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 24 h / 90 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / methanol / 7.5 h

With copper(l) iodide; hydrogen; triethylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;