(3-bromo-4-phenyl-2-trifluoromethyl-but-2-enyloxy)-tert-butyl-dimethyl-silane

Base Information

• Chemical Name: (3-bromo-4-phenyl-2-trifluoromethyl-but-2-enyloxy)-tert-butyl-dimethyl-silane
• CAS No.: 903503-87-7
• Molecular Formula: C₁₇H₂₄BrF₃OSi
• Molecular Weight: 409.362
• Mol file: 903503-87-7.mol

Synonyms:(3-bromo-4-phenyl-2-trifluoromethyl-but-2-enyloxy)-tert-butyl-dimethyl-silane

Chemical Property of (3-bromo-4-phenyl-2-trifluoromethyl-but-2-enyloxy)-tert-butyl-dimethyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-bromo-4-phenyl-2-trifluoromethyl-but-2-enyloxy)-tert-butyl-dimethyl-silane

There total 1 articles about (3-bromo-4-phenyl-2-trifluoromethyl-but-2-enyloxy)-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

1,1,1-trifluoro-2-[(tert-butyldimethylsilyloxy)methyl]-3,3-dibromo-prop-2-ene + benzyl bromide (100-39-0) → (3-bromo-4-phenyl-2-trifluoromethyl-but-2-enyloxy)-tert-butyl-dimethyl-silane (903503-87-7)

Guidance literature:

1,1,1-trifluoro-2-[(tert-butyldimethylsilyloxy)methyl]-3,3-dibromo-prop-2-ene; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

benzyl bromide; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2006.04.110

Reference yield: 59.0%

(3-bromo-4-phenyl-2-trifluoromethyl-but-2-enyloxy)-tert-butyl-dimethyl-silane (903503-87-7) + phenylacetylene (536-74-3) → (3-benzyl-5-phenyl-2-trifluoromethyl-pent-2-en-4-ynyloxy)-tert-butyl-dimethyl-silane (903504-03-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine;

DOI:10.1016/j.tetlet.2006.04.110

Reference yield: 55.0%

(3-bromo-4-phenyl-2-trifluoromethyl-but-2-enyloxy)-tert-butyl-dimethyl-silane (903503-87-7) + 4-ethynylbenzoic acid methyl ester (3034-86-4) → 4-[3-benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5,5,5-trifluoro-pent-3-en-1-ynyl]-benzoic acid methyl ester (903504-05-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine;

DOI:10.1016/j.tetlet.2006.04.110

upstream raw materials:

benzyl bromide

Downstream raw materials:

4-[3-benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5,5,5-trifluoro-pent-3-en-1-ynyl]-benzoic acid methyl ester

(3-benzyl-5-phenyl-2-trifluoromethyl-pent-2-en-4-ynyloxy)-tert-butyl-dimethyl-silane

[3-benzyl-5-(4-methoxy-phenyl)-2-trifluoromethyl-pent-2-en-4-ynyloxy]-tert-butyl-dimethyl-silane