1-[4-(4,6-difluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]-4-{[2-(methyloxy)ethyl]oxy}cyclohexanecarbonitrile

Base Information

Chemical Name:1-[4-(4,6-difluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]-4-{[2-(methyloxy)ethyl]oxy}cyclohexanecarbonitrile
CAS No.:1065652-87-0
Molecular Formula:C₂₂H₂₈F₂N₄O₃
Molecular Weight:434.486
Hs Code.:

Synonyms:1-[4-(4,6-difluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]-4-{[2-(methyloxy)ethyl]oxy}cyclohexanecarbonitrile

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Chemical Property of 1-[4-(4,6-difluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]-4-{[2-(methyloxy)ethyl]oxy}cyclohexanecarbonitrile

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Technology Process of 1-[4-(4,6-difluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]-4-{[2-(methyloxy)ethyl]oxy}cyclohexanecarbonitrile

There total 8 articles about 1-[4-(4,6-difluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]-4-{[2-(methyloxy)ethyl]oxy}cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 107025-45-6
4-(2-methoxyethoxy)cyclohexanone

: 1065652-85-8
4,6-difluoro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 1065652-87-0
1-[4-(4,6-difluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]-4-{[2-(methyloxy)ethyl]oxy}cyclohexanecarbonitrile

Guidance literature:: 4-(2-methoxyethoxy)cyclohexanone; 4,6-difluoro-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride; 2-hydroxy-2-methylpropanenitrile; With magnesium sulfate; In N,N-dimethyl acetamide; at 60 - 70 ℃; for 48h;

With water; In dichloromethane; N,N-dimethyl acetamide; at 20 ℃; for 0.5h;

Reference yield:

: 1065652-77-8
8-{[2-(methyloxy)ethyl]oxy}-1,4-dioxaspiro[4.5]decane

: 1065652-87-0
1-[4-(4,6-difluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]-4-{[2-(methyloxy)ethyl]oxy}cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / tetrahydrofuran / 20 °C

2.1: magnesium sulfate / N,N-dimethyl acetamide / 48 h / 60 - 70 °C

2.2: 0.5 h / 20 °C

With hydrogenchloride; water; magnesium sulfate; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 22428-87-1
4,4-ethylenedioxycyclohexan-1-ol

: 1065652-87-0
1-[4-(4,6-difluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinyl]-4-{[2-(methyloxy)ethyl]oxy}cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0 - 40 °C

2.1: hydrogenchloride; water / tetrahydrofuran / 20 °C

3.1: magnesium sulfate / N,N-dimethyl acetamide / 48 h / 60 - 70 °C

3.2: 0.5 h / 20 °C

With hydrogenchloride; water; sodium hydride; magnesium sulfate; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;