Technology Process of (E)-3-((4S,5S)-5-((R)-1-(tert-butyldiphenylsilyloxy)butyl)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylaldehyde
There total 8 articles about (E)-3-((4S,5S)-5-((R)-1-(tert-butyldiphenylsilyloxy)butyl)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Hoveyda-Grubbs catalyst second generation;
In
dichloromethane;
for 6h;
stereoselective reaction;
Reflux;
DOI:10.1016/j.tetlet.2011.12.119
- Guidance literature:
-
Multi-step reaction with 4 steps
1: CSA
2: diisobutylaluminium hydride / dichloromethane / -78 °C
3: lithium hexamethyldisilazane / 1 h / 0 °C
4: Hoveyda-Grubbs catalyst second generation / dichloromethane / 6 h / Reflux
With
Hoveyda-Grubbs catalyst second generation; diisobutylaluminium hydride; lithium hexamethyldisilazane;
In
dichloromethane;
3: Wittig reaction;
DOI:10.1016/j.tetlet.2011.12.119
- Guidance literature:
-
Multi-step reaction with 5 steps
1: AD-mix β; methanesulfonamide; water / tert-butyl alcohol / 24 h / 20 °C
2: CSA
3: diisobutylaluminium hydride / dichloromethane / -78 °C
4: lithium hexamethyldisilazane / 1 h / 0 °C
5: Hoveyda-Grubbs catalyst second generation / dichloromethane / 6 h / Reflux
With
Hoveyda-Grubbs catalyst second generation; methanesulfonamide; AD-mix β; water; diisobutylaluminium hydride; lithium hexamethyldisilazane;
In
dichloromethane; tert-butyl alcohol;
1: Sharpless dihydroxylation / 4: Wittig reaction;
DOI:10.1016/j.tetlet.2011.12.119
