Technology Process of (2R,3S,4R)-ethyl 4-(tert-butyldiphenylsilyloxy)-2,3-dihydroxyheptanoate
There total 4 articles about (2R,3S,4R)-ethyl 4-(tert-butyldiphenylsilyloxy)-2,3-dihydroxyheptanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diisobutylaluminium hydride / dichloromethane / -78 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C
2.2: 0 °C
3.1: AD-mix β; methanesulfonamide; water / tert-butyl alcohol / 24 h / 20 °C
With
methanesulfonamide; AD-mix β; water; sodium hydride; diisobutylaluminium hydride;
In
tetrahydrofuran; dichloromethane; mineral oil; tert-butyl alcohol;
2.1: Horner-Wadsworth-Emmons olefination / 2.2: Horner-Wadsworth-Emmons olefination / 3.1: Sharpless dihydroxylation;
DOI:10.1016/j.tetlet.2011.12.119
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1H-imidazole; dmap / 12 h
2.1: diisobutylaluminium hydride / dichloromethane / -78 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C
3.2: 0 °C
4.1: AD-mix β; methanesulfonamide; water / tert-butyl alcohol / 24 h / 20 °C
With
1H-imidazole; dmap; methanesulfonamide; AD-mix β; water; sodium hydride; diisobutylaluminium hydride;
In
tetrahydrofuran; dichloromethane; mineral oil; tert-butyl alcohol;
3.1: Horner-Wadsworth-Emmons olefination / 3.2: Horner-Wadsworth-Emmons olefination / 4.1: Sharpless dihydroxylation;
DOI:10.1016/j.tetlet.2011.12.119
