3-bromo-4,5-diphenylisothiazole

Base Information

• Chemical Name: 3-bromo-4,5-diphenylisothiazole
• CAS No.: 942227-85-2
• Molecular Formula: C₁₅H₁₀BrNS
• Molecular Weight: 316.221
• Mol file: 942227-85-2.mol

Synonyms:3-bromo-4,5-diphenylisothiazole

Chemical Property of 3-bromo-4,5-diphenylisothiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromo-4,5-diphenylisothiazole

There total 11 articles about 3-bromo-4,5-diphenylisothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-hydroxy-4,5-diphenylisothiazole (37120-50-6) → 3-bromo-4,5-diphenylisothiazole (942227-85-2)

Guidance literature:

With phosphorus(V) oxybromide; at 100 ℃; for 24h;

DOI:10.1039/b702154b

Reference yield:

3-chloro-5-phenylisothiazole-4-carboxamide (457960-33-7) → 3-bromo-4,5-diphenylisothiazole (942227-85-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 83 percent / aq. sodium hydroxide; Br₂ / 1 h / 20 - 70 °C

2: 82 percent / I₂; isoamyl nitrite / acetonitrile / 0.33 h / 80 °C

3: 98 percent / K₂CO₃ / Pd(OAc)2 / dimethylformamide / 0.67 h / 100 °C

4: 95 percent / aq. KOH / 24 h / 200 °C / 12929 Torr

5: 85 percent / POBr₃ / 24 h / 100 °C

With potassium hydroxide; sodium hydroxide; bromine; iodine; potassium carbonate; phosphorus(V) oxybromide; isopentyl nitrite; palladium diacetate; In N,N-dimethyl-formamide; acetonitrile; 1: Hoffmann degradation / 3: Suzuki reaction;

DOI:10.1039/b702154b

Reference yield:

4-amino-3-chloro-5-phenylisothiazole (942227-80-7) → 3-bromo-4,5-diphenylisothiazole (942227-85-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / I₂; isoamyl nitrite / acetonitrile / 0.33 h / 80 °C

2: 98 percent / K₂CO₃ / Pd(OAc)2 / dimethylformamide / 0.67 h / 100 °C

3: 95 percent / aq. KOH / 24 h / 200 °C / 12929 Torr

4: 85 percent / POBr₃ / 24 h / 100 °C

With potassium hydroxide; iodine; potassium carbonate; phosphorus(V) oxybromide; isopentyl nitrite; palladium diacetate; In N,N-dimethyl-formamide; acetonitrile; 2: Suzuki reaction;

DOI:10.1039/b702154b

upstream raw materials:

3-hydroxy-4,5-diphenylisothiazole

3-amino-4,5-diphenylisothiazole

3-chloro-5-phenylisothiazole-4-carboxamide

silver 3-chloro-5-phenylisothiazole-4-carboxylate