5-n-Butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2-[2-chloro-5-(propionylamino)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:5-n-Butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2-[2-chloro-5-(propionylamino)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS No.:159547-33-8
Molecular Formula:C₃₂H₃₇ClFN₅O₄S
Molecular Weight:642.194
Hs Code.:

Synonyms:5-n-Butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2-[2-chloro-5-(propionylamino)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

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Chemical Property of 5-n-Butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2-[2-chloro-5-(propionylamino)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

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Technology Process of 5-n-Butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2-[2-chloro-5-(propionylamino)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 10 articles about 5-n-Butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2-[2-chloro-5-(propionylamino)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 598-22-1
propanoyl bromide

: 159547-32-7
2-(5-Amino-2-chlorophenyl)-5-n-butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]-methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

: 159547-33-8
5-n-Butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2-[2-chloro-5-(propionylamino)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: With dmap; In pyridine; Ambient temperature;
DOI:10.1021/jm00019a004

Reference yield:

: 5133-68-6
ethyl N-carbethoxyvalerimidate

: 159547-33-8
5-n-Butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2-[2-chloro-5-(propionylamino)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 2.) Et₃N / 1.) toluene, 65 deg C, 4 h, 2.) toluene, 90 deg C, 16 h

2: 1.) NaH / 1.) DMF, 50 deg C, 3 h, 2.) DMF, 90 deg C, overnight

3: 52 percent / 1.25 N aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene; ethanol / 4 h / 90 °C

4: 78 percent / H₂ / PtO₂ / ethanol / 3 h

5: 84 percent / DMAP / pyridine / Ambient temperature

With dmap; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium hydride; triethylamine; platinum(IV) oxide; In pyridine; ethanol; toluene;
DOI:10.1021/jm00019a004

Reference yield:

: 96701-59-6
(2-chloro-5-nitrophenyl)hydrazine

: 159547-33-8
5-n-Butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2-[2-chloro-5-(propionylamino)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 2.) Et₃N / 1.) toluene, 65 deg C, 4 h, 2.) toluene, 90 deg C, 16 h

2: 1.) NaH / 1.) DMF, 50 deg C, 3 h, 2.) DMF, 90 deg C, overnight

3: 52 percent / 1.25 N aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene; ethanol / 4 h / 90 °C

4: 78 percent / H₂ / PtO₂ / ethanol / 3 h

5: 84 percent / DMAP / pyridine / Ambient temperature

With dmap; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium hydride; triethylamine; platinum(IV) oxide; In pyridine; ethanol; toluene;
DOI:10.1021/jm00019a004