96701-59-6

Basic information

• Product Name: 1-(2-CHLORO-5-NITROPHENYL)HYDRAZINE
• Synonyms: 2-CHLORO-5-NITRO-PHENYL-HYDRAZINE;1-(2-CHLORO-5-NITROPHENYL)HYDRAZINE
• CAS NO: 96701-59-6
• Molecular Formula: C₆H₆ClN₃O₂
• Molecular Weight: 187.58
• Mol File: 96701-59-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 160 °C
• Boiling Point: 313.8±32.0 °C(Predicted)
• Appearance: /
• Density: 1.565±0.06 g/cm3(Predicted)
• PKA: 3.77±0.10(Predicted)
• CAS DataBase Reference: 1-(2-CHLORO-5-NITROPHENYL)HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-CHLORO-5-NITROPHENYL)HYDRAZINE(96701-59-6)
• EPA Substance Registry System: 1-(2-CHLORO-5-NITROPHENYL)HYDRAZINE(96701-59-6)

Safety Data

• Hazardous Substances Data: 96701-59-6(Hazardous Substances Data)

Usage

General Description

1-(2-Chloro-5-nitrophenyl)hydrazine is a chemical compound with the molecular formula C6H6ClN3O2. It is an organic compound that contains a hydrazine functional group and a nitrophenyl moiety. 1-(2-CHLORO-5-NITROPHENYL)HYDRAZINE is commonly used in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential as a corrosion inhibitor and as a precursor to various heterocyclic compounds. 1-(2-Chloro-5-nitrophenyl)hydrazine is known for its toxic and irritating properties and should be handled with care.

Upstream product

• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 

Downstream Products

• 1195072-97-9 C₉H₆ClN₃O₂ 

Relevant articles and documents

AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) via inhibition of a methyltransfera

GDC-0449-A potent inhibitor of the hedgehog pathway

SAR for a wide variety of heterocyclic replacements for a benzimidazole led to the discovery of functionalized 2-pyridyl amides as novel inhibitors of the hedgehog pathway. The 2-pyridyl amides were optimized for potency, PK, and drug-like properties by modifications to the amide portion of the molecule resulting in 31 (GDC-0449). Amide 31 produced complete tumor regression at doses as low as 12.5 mg/kg BID in a medulloblastoma allograft mouse model that is wholly dependent on the Hh pathway for growth and is currently in human clinical trials, where it is initially being evaluated for the treatment of BCC.