96701-59-6

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
1-(2-Chloro-5-nitrophenyl)hydrazine is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Corrosion Inhibition:
As a potential corrosion inhibitor, 1-(2-Chloro-5-nitrophenyl)hydrazine is utilized in the industry to protect metals from corrosion, enhancing the durability and longevity of materials.
Used as a Precursor to Heterocyclic Compounds:
1-(2-Chloro-5-nitrophenyl)hydrazine serves as a precursor in the production of various heterocyclic compounds, which are essential in the chemical and pharmaceutical industries for creating a wide range of products.
Used in Chemical Research:
In the field of chemical research, 1-(2-Chloro-5-nitrophenyl)hydrazine is employed as a reagent for studying the properties and reactions of hydrazine and nitrophenyl groups, furthering the understanding of these functional groups and their applications in chemical synthesis.

Upstream product

• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 

Downstream Products

• 146949-03-3 5-n-butyl-2-(2-chloro-5-nitrophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1195072-97-9 C₉H₆ClN₃O₂ 
• 858442-15-6 2-(2-chloro-4-nitro-phenyl)-4-methyl-2H-phthalazin-1-one 
• 856804-94-9 2-(2-chloro-5-nitro-phenyl)-2H-phthalazin-1-one 

Relevant academic research and scientific papers

AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) via inhibition of a methyltransfera

Novel Anthranilic Diamide Scaffolds Containing N-Substituted Phenylpyrazole as Potential Ryanodine Receptor Activators

To discover potent insecticides targeting ryanodine receptors (RyRs), a series of novel anthranilic diamides analogues (12a-12u) containing N-substituted phenylpyrazole were designed and synthesized. These compounds were characterized by 1H NMR, 13C NMR, and HRMS, and the structure of compound 12u was confirmed by X-ray diffraction. Their insecticidal activities indicated that these compounds displayed moderate to excellent activities. In particular, 12i showed 100 and 37% larvicidal activities against oriental armyworm (Mythimna separata) at 0.25 and 0.05 mg L-1, equivalent to that of chlorantraniliprole (100%, 0.25 mg L-1; and 33%, 0.05 mg L-1). The activity of 12i against diamondback moth (Plutella xylostella) was 95% at 0.05 mg L-1, whereas the control was 100% at 0.05 mg L-1. The calcium-imaging technique experiment results showed that the effects of 12i on the intracellular calcium ion concentration ([Ca2+]i) in neurons were concentration-dependent. After the central neurons of Helicoverpa armigera were dyed by loading with fluo-5N and treated with 12i, the free calcium released in endoplasmic reticulum indicated the target of compound 12i is RyRs or IP3Rs. The activation of RyRs by natural ryanodine completely blocked the calcium release induced by 12i, which indicated that RyRs in the central neurons of H. armigera third-instar larvae is the possible target of compound 12i.

GDC-0449-A potent inhibitor of the hedgehog pathway

SAR for a wide variety of heterocyclic replacements for a benzimidazole led to the discovery of functionalized 2-pyridyl amides as novel inhibitors of the hedgehog pathway. The 2-pyridyl amides were optimized for potency, PK, and drug-like properties by modifications to the amide portion of the molecule resulting in 31 (GDC-0449). Amide 31 produced complete tumor regression at doses as low as 12.5 mg/kg BID in a medulloblastoma allograft mouse model that is wholly dependent on the Hh pathway for growth and is currently in human clinical trials, where it is initially being evaluated for the treatment of BCC.