(5E)-5-phenylthio-PGI₂ 11,15-O-bis(t-butyldimethylsilyl) methyl ester

Base Information

• Chemical Name: (5E)-5-phenylthio-PGI₂ 11,15-O-bis(t-butyldimethylsilyl) methyl ester
• CAS No.: 78824-84-7
• Molecular Formula: C₃₉H₆₆O₅SSi₂
• Molecular Weight: 703.187
• Mol file: 78824-84-7.mol

Synonyms:(5E)-5-phenylthio-PGI₂ 11,15-O-bis(t-butyldimethylsilyl) methyl ester

Chemical Property of (5E)-5-phenylthio-PGI₂ 11,15-O-bis(t-butyldimethylsilyl) methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5E)-5-phenylthio-PGI₂ 11,15-O-bis(t-butyldimethylsilyl) methyl ester

There total 2 articles about (5E)-5-phenylthio-PGI₂ 11,15-O-bis(t-butyldimethylsilyl) methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(5R)-5-phenylthio-δ-PGI1 11,15-O-bis(t-butyldimethylsilyl) methyl ester (78824-83-6) → (5E)-5-phenylthio-PGI2 11,15-O-bis(t-butyldimethylsilyl) methyl ester (78824-84-7)

Guidance literature:

With sulfuric acid; Ambient temperature;

DOI:10.1016/S0040-4039(01)90337-5

Reference yield: 68.0%

11,15-O-bis(tert-butyldimethylsilyl)PGI2 methyl ester (78824-82-5) + benzenesulfenyl chloride (931-59-9) → (5E)-5-phenylthio-PGI2 11,15-O-bis(t-butyldimethylsilyl) methyl ester (78824-84-7)

Guidance literature:

In dichloromethane; at -78 ℃; for 0.25h;

DOI:10.1016/S0040-4020(01)88623-3

Reference yield: 70.0%

(5E)-5-phenylthio-PGI2 11,15-O-bis(t-butyldimethylsilyl) methyl ester (78824-84-7) → (5E)-5-phenylthio-PGI2 methyl ester (75636-73-6)

Guidance literature:

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1016/S0040-4020(01)88623-3

upstream raw materials:

(5R)-5-phenylthio-δ-PGI₁ 11,15-O-bis(t-butyldimethylsilyl) methyl ester

11,15-O-bis(tert-butyldimethylsilyl)PGI₂ methyl ester

benzenesulfenyl chloride

Downstream raw materials:

(5E)-5-phenylthio-PGI₂ methyl ester

(5E)-5-phenethylsulfinyl-PGI₂ methyl ester