1081-79-4Relevant academic research and scientific papers
p-Tyrosol: a new synthetic method and new types of pharmacological activity
Sysolyatin,Kryukov, Yu. A.,Malykhin,Muradov,Chernysheva,Aliev,Smol’yakova,Anishchenko,Sidekhmenova,Shamanaev, A. Yu.,Plotnikov
, p. 2210 - 2214 (2016/10/03)
A new method for the synthesis of p-tyrosol, i.e., 2-(4-hydroxyphenyl)ethanol, has been developed, which considerably simplified the process of preparation of this pharmaceutical substance. The method includes nitration of 2-phenylethanol, catalytic hydrogenation of 2-(4nitrophenyl)ethyl nitrate, and nitrosation of 2-(4-aminophenyl)ethanol, followed by acid hydrolysis of the intermediate diazo compound. The method is easily feasible, furnishes the pharmaceutical substance of high quality, and is quite acceptable for commercialization. Antihypertensive and hemorheologic activities of p-tyrosol in spontaneously hypertensive rats were investigated per se and in combination with captopril. p-Tyrosol in the course administration with captopril was found to enhance the antihypertensive effect of the latter and eliminate its negative effect on red blood cell aggregation.
CHEMISTRY OF NITRO ETHERS. XVIII. SIMPLIFIED SYNTHESIS OF 2-(4-NITROPHENYL)ETHANOL
Kochergin, P. M.,Blinova, L. S.
, p. 1556 - 1558 (2007/10/03)
A method was developed for the preparative synthesis of 2-(4-nitrophenyl)ethanol by the nitration of 2-phenylethanol followed by acid hydrolysis of 2-(4-nitrophenyl)ethyl nitrate.
