1-(2',4',5'-trimethoxybenzyl)-6,7-bis(benzyloxy)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(2',4',5'-trimethoxybenzyl)-6,7-bis(benzyloxy)-1,2,3,4-tetrahydroisoquinoline
CAS No.:72943-40-9
Molecular Formula:C₃₃H₃₅NO₅
Molecular Weight:525.645
Hs Code.:

Synonyms:1-(2',4',5'-trimethoxybenzyl)-6,7-bis(benzyloxy)-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2',4',5'-trimethoxybenzyl)-6,7-bis(benzyloxy)-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 1-(2',4',5'-trimethoxybenzyl)-6,7-bis(benzyloxy)-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about 1-(2',4',5'-trimethoxybenzyl)-6,7-bis(benzyloxy)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 72943-39-6
6,7-Bis-benzyloxy-1-(2,4,5-trimethoxy-benzyl)-3,4-dihydro-isoquinoline

: 72943-40-9
1-(2',4',5'-trimethoxybenzyl)-6,7-bis(benzyloxy)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium tetrahydroborate; In methanol; for 18h; Ambient temperature;
DOI:10.1021/jm00177a027

Reference yield:

: 63359-53-5
2,4,5-trimethoxyphenylacetyl chloride

: 72943-40-9
1-(2',4',5'-trimethoxybenzyl)-6,7-bis(benzyloxy)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaHCO₃ / CHCl₃ / 15 h / Ambient temperature

2: 924 mg / POCl₃ / acetonitrile / 2 h / Heating

3: 97 percent / NaBH₄ / methanol / 18 h / Ambient temperature

With sodium tetrahydroborate; sodium hydrogencarbonate; trichlorophosphate; In methanol; chloroform; acetonitrile;
DOI:10.1021/jm00177a027

Reference yield:

: 4463-16-5
2,4,5-trimethoxyphenylacetic acid

: 72943-40-9
1-(2',4',5'-trimethoxybenzyl)-6,7-bis(benzyloxy)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / benzene / 3 h / Heating

2: aq. NaHCO₃ / CHCl₃ / 15 h / Ambient temperature

3: 924 mg / POCl₃ / acetonitrile / 2 h / Heating

4: 97 percent / NaBH₄ / methanol / 18 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; sodium hydrogencarbonate; trichlorophosphate; In methanol; chloroform; acetonitrile; benzene;
DOI:10.1021/jm00177a027