Benzeneacetic acid, 2,4,5-triMethoxy-

Base Information

• Chemical Name: Benzeneacetic acid, 2,4,5-triMethoxy-
• CAS No.: 4463-16-5
• Molecular Formula: C11H14 O5
• Molecular Weight: 226.229
• Mol file: 4463-16-5.mol

Synonyms:Aceticacid, (2,4,5-trimethoxyphenyl)- (6CI,7CI,8CI); Homoasaronic acid

Chemical Property of Benzeneacetic acid, 2,4,5-triMethoxy-

Chemical Property:

• PSA: 64.99000
• LogP: 1.33950

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, 2,4,5-triMethoxy-

There total 13 articles about Benzeneacetic acid, 2,4,5-triMethoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenyl-4-(2,4,5-trimethoxy-benzylidene)-4H-oxazol-5-one (22892-39-3) → 2,4,5-trimethoxyphenylacetic acid (4463-16-5)

Guidance literature:

2-phenyl-4-(2,4,5-trimethoxy-benzylidene)-4H-oxazol-5-one; With sodium hydroxide; In water; for 10h; Reflux;

With dihydrogen peroxide; sodium hydroxide; In water; at 15 - 20 ℃;

DOI:10.1016/j.tet.2016.04.066

Reference yield:

2,4,5-trimethoxybenzeneacetonitrile (38444-50-7) → 2,4,5-trimethoxyphenylacetic acid (4463-16-5)

Guidance literature:

With potassium hydroxide;

DOI:10.1039/jr9350001371

Reference yield:

2,4,5-trimethoxybenzyl chloride (53811-44-2) → 2,4,5-trimethoxyphenylacetic acid (4463-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylsulfoxide

2: 19 percent aq. NaOH / ethanol

With sodium hydroxide; In ethanol; dimethyl sulfoxide;

DOI:10.1016/S0960-894X(02)00291-3

upstream raw materials:

2,4,5-trimethoxybenzeneacetonitrile

(2,4,5-trimethoxy-phenyl)-pyruvic acid

(2,4,5-trihydroxy-phenyl)-acetic acid

dimethyl sulfate

Downstream raw materials:

asaronic acid

(2,4,5-trimethoxy-phenyl)-acetic acid amide

2-<2,4,5-Trimethoxy-phenyl>-aethanol

N-β-<(3,4-dimethoxyphenyl)ethyl>-2,4,5-trimethoxyphenylacetamide

Refernces

• 1、 Lin, Yun-Loung,Huang, Jian-Lin,Wu, Chung-Shieh,Liu, Hung-Ge,Yang, Ding-Yah. "Design, synthesis, and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hydroxyphenylpyruvate dioxygenase". . p. 1709 - 1713. Retrieved 2007/10/03.