(R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-octanoic acid

Base Information

Chemical Name:(R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-octanoic acid
CAS No.:123382-12-7
Molecular Formula:C₂₉H₅₁NO₅Si
Molecular Weight:521.813
Hs Code.:

Synonyms:(R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-octanoic acid

Suppliers and Price of (R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-octanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-octanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-octanoic acid

There total 1 articles about (R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-octanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123411-06-3
[1-((2R,4R)-4-Hexyl-5-oxo-tetrahydro-furan-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 123382-12-7
(R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-octanoic acid

Guidance literature:: With 1H-imidazole; lithium hydroxide; Multistep reaction; 1.) dioxane, water, RT, overnight, 2.) DMF, 3 days;
DOI:10.1021/jm00163a059

Reference yield:

: 123382-12-7
(R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-octanoic acid

: 118233-41-3
(4S,5S)-5-Amino-6-cyclohexyl-4-hydroxy-2-methylene-hexanoic acid isobutyl-amide; hydrochloride

: [(1S,2R,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-((1S,2S)-1-cyclohexylmethyl-2-hydroxy-4-isobutylcarbamoyl-pent-4-enylcarbamoyl)-decyl]-carbamic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at -23 ℃; for 2h;
DOI:10.1021/jm00163a059

Reference yield:

: 123382-12-7
(R)-2-[(2R,3S)-3-tert-Butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyl]-octanoic acid

: 123411-31-4
[(1S,2R,4R)-1-Benzyl-4-((1S,2S)-1-cyclohexylmethyl-2-hydroxy-4-isobutylcarbamoyl-pent-4-enylcarbamoyl)-2-hydroxy-decyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxybenzotriazole monohydrate, 4-methylmorpholine, 1-ethyl-3-<3-(dimethylamino)propyl>-carbodiimide hydrochloride / dimethylformamide / 2 h / -23 °C

2: tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / Ambient temperature

With 4-methyl-morpholine; tetrabutyl ammonium fluoride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a059