2-chloro-6-fluoropyridin-4-amine

Base Information

Chemical Name:2-chloro-6-fluoropyridin-4-amine
CAS No.:1352830-76-2
Molecular Formula:C₅H₄ClFN₂
Molecular Weight:146.552
Hs Code.:

Synonyms:2-chloro-6-fluoropyridin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-chloro-6-fluoropyridin-4-amine

Chemical Property:

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Technology Process of 2-chloro-6-fluoropyridin-4-amine

There total 3 articles about 2-chloro-6-fluoropyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1352830-73-9
C₂₄H₁₈Cl₂N₂

: 1352830-76-2
2-chloro-6-fluoropyridin-4-amine

: 63489-58-7
4-amino-2,6-difluoropyridine

Guidance literature:: C₂₄H₁₈Cl₂N₂; With potassium fluoride; [2.2.2]cryptande; In dimethyl sulfoxide; at 160 ℃; for 72h;

With hydrogenchloride; In methanol; for 1h;

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1352830-76-2
2-chloro-6-fluoropyridin-4-amine

Guidance literature:: Multi-step reaction with 7 steps

1: 0.5 h / 150 °C / Microwave irradiation

2: dichloromethane; methanol / 0.42 h / 0 - 25 °C

3: triethylamine / dichloromethane / 0.5 h / 25 °C

4: sodium hydroxide; water / tetrahydrofuran / 3 h / 0 - 25 °C

5: triethylamine; diphenyl phosphoryl azide / toluene / 16 h / 110 °C

6: pyridine hydrogenfluoride; sodium nitrite / 2 h / 0 - 25 °C

7: hydrogen; platinum(IV) oxide / methanol / 16 h / 25 °C / Inert atmosphere

With platinum(IV) oxide; diphenyl phosphoryl azide; water; hydrogen; pyridine hydrogenfluoride; triethylamine; sodium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 1352830-76-2
2-chloro-6-fluoropyridin-4-amine

: 63489-58-7
4-amino-2,6-difluoropyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h

2.1: potassium fluoride; [2.2.2]cryptande / dimethyl sulfoxide / 72 h / 160 °C

2.2: 1 h

With potassium fluoride; N-ethyl-N,N-diisopropylamine; [2.2.2]cryptande; In dichloromethane; dimethyl sulfoxide;