2,6-Difluoropyridin-4-amine

Base Information

• Chemical Name: 2,6-Difluoropyridin-4-amine
• CAS No.: 63489-58-7
• Molecular Formula: C5H4F2N2
• Molecular Weight: 130.097
• Hs Code.: 2933399090
• European Community (EC) Number: 811-917-8
• ChEMBL ID: CHEMBL117189
• DSSTox Substance ID: DTXSID20461139
• Mol file: 63489-58-7.mol

Synonyms:2,6-difluoropyridin-4-amine;63489-58-7;4-Amino-2,6-difluoropyridine;2,,6-difluoro-4-aminopyridine;MFCD08436089;4-Pyridinamine, 2,6-difluoro-;2,6-difluoro-4-pyridinamine;CHEMBL117189;SCHEMBL4858631;DTXSID20461139;OWXBXLGJIFPPMS-UHFFFAOYSA-N;(2,6-difluoro-pyridin-4-yl)-amine;AKOS006339208;CS-W005329;SB21220;AS-41531;SY040109;AM20061397;FT-0705612;A26083;EN300-117234

Chemical Property of 2,6-Difluoropyridin-4-amine

Chemical Property:

• Vapor Pressure: 0.00799mmHg at 25°C
• Melting Point: 124-125
• Refractive Index: 1.524
• Boiling Point: 267.8°C at 760 mmHg
• PKA: -0.33±0.10(Predicted)
• Flash Point: 115.7°C
• PSA: 38.91000
• Density: 1.393g/cm³
• LogP: 1.52320
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 130.03425446
• Heavy Atom Count: 9
• Complexity: 89

Purity/Quality:

97% ^*data from raw suppliers

2,6-difluoropyridin-4-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(N=C1F)F)N

Technology Process of 2,6-Difluoropyridin-4-amine

There total 8 articles about 2,6-Difluoropyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.6%

4-amino-3,5-dichloro-2,6-difluoropyridine (2840-00-8) → 4-amino-2,6-difluoropyridine (63489-58-7)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; for 72h; under 2689.2 Torr;

DOI:10.1021/jm00385a016

Reference yield: 57.0%

4-amino-3,5-dichloro-2,6-difluoropyridine (2840-00-8) → 4-amino-2,6-difluoropyridine (63489-58-7) + 4-amino-3-chloro-2,6-difluoropyridine (405230-78-6)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; for 18h; under 2585.74 Torr;

DOI:10.1081/NCN-100108327

Reference yield: 37.0%

C24H18Cl2N2 (1352830-73-9) → 2-chloro-6-fluoropyridin-4-amine (1352830-76-2) + 4-amino-2,6-difluoropyridine (63489-58-7)

Guidance literature:

C₂₄H₁₈Cl₂N₂; With potassium fluoride; [2.2.2]cryptande; In dimethyl sulfoxide; at 160 ℃; for 72h;

With hydrogenchloride; In methanol; for 1h;

upstream raw materials:

4-amino-3,5-dichloro-2,6-difluoropyridine

3,5-dichloro-2,4,6-trifluoropyridine

2,6-dichloro-[4]pyridylamine

C₂₄H₁₈Cl₂N₂

Downstream raw materials:

2-fluoro-6-methoxypyridin-4-amine

4,6-difluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-c]pyridine

4-amino-6-fluoro-1-(2,3,5-tri-O-benzyl-α-D-arabinofuranosyl)imidazo[4,5-c]pyridine

4-amino-6-fluoro-1-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)imidazo[4,5-c]pyridine