17β-hydroxy-19-nor-5β-androstan-3-one

Base Information

• Chemical Name: 17β-hydroxy-19-nor-5β-androstan-3-one
• CAS No.: 19468-31-6
• Molecular Formula: C₁₈H₂₈O₂
• Molecular Weight: 276.419
• Mol file: 19468-31-6.mol

Synonyms:17β-hydroxy-19-nor-5β-androstan-3-one

Chemical Property of 17β-hydroxy-19-nor-5β-androstan-3-one

Chemical Property:

• Melting Point: 106-108 °C
• Boiling Point: 412.9±45.0 °C(Predicted)
• Density: 1.093±0.06 g/cm3(Predicted)

Purity/Quality:

95%-98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17β-hydroxy-19-nor-5β-androstan-3-one

There total 3 articles about 17β-hydroxy-19-nor-5β-androstan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

C18H27IO2 + iodomethylbenzoate (13943-33-4) → 5a-dihydro-18-(benzoyloxymethylene)-19-nortestosterone + 19-norDHT (1434-85-1,19468-31-6,19685-03-1,20796-76-3,20796-77-4,20796-78-5,20796-79-6,22786-91-0,22786-93-2,94424-26-7,94424-28-9)

Guidance literature:

With manganese; copper dichloride; In tetrahydrofuran; water; at 20 ℃; for 24h;

Reference yield: 16.0%

19-nortestosterone (434-22-0) → 17β-hydroxy-5α-estran-3-one (1434-85-1) + 5α‐estrane‐3β,17β‐diol (1816-75-7) + 5β‐estrane‐3α,17β‐diol (10002-97-8) + 17β-hydroxy-19-nor-5β-androstan-3-one (19468-31-6)

Guidance literature:

With potassium hydroxide; hydrogen; palladium on activated charcoal; In isopropyl alcohol; under 2068.6 - 2327.2 Torr; Yields of byproduct given; Ambient temperature;

DOI:10.1021/jm960304p

Reference yield:

19-nortestosterone (434-22-0) → 17β-hydroxy-5α-estran-3-one (1434-85-1) + 5β‐estrane‐3α,17β‐diol (10002-97-8) + 17β-hydroxy-19-nor-5β-androstan-3-one (19468-31-6) + 5β-estrane-3,17-dione (5696-51-5)

Guidance literature:

With chromium(VI) oxide; potassium hydroxide; sulfuric acid; hydrogen; palladium on activated charcoal; Yield given. Multistep reaction. Title compound not separated from byproducts; 1.) 2-propanol, from 40 to 45 psi, RT, 2.) acetone, RT, 30 min;

DOI:10.1021/jm960304p

upstream raw materials:

iodomethylbenzoate

19-nortestosterone

Downstream raw materials:

(5β,17β)-17-hydroxyestran-3-one 17-tosylate

(3α,5α,17β)-estrane-3,17-diol 17-tosylate

5β-estrane-3,17-dione

5β‐estrane‐3α,17β‐diol

Refernces

• 1、 -. "HELIX 12 DIRECTED STEROIDAL PHARMACEUTICAL PRODUCTS". Page/Page column 128-129. . Retrieved 2010/02/12.