(1-{3-[5-(3,4-dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]-propylcarbamoyl}-2-thiazol-2-yl-ethyl)-(S)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(1-{3-[5-(3,4-dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]-propylcarbamoyl}-2-thiazol-2-yl-ethyl)-(S)-carbamic acid tert-butyl ester
CAS No.:1312304-13-4
Molecular Formula:C₃₁H₃₇N₅O₆S
Molecular Weight:607.731
Hs Code.:

Synonyms:(1-{3-[5-(3,4-dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]-propylcarbamoyl}-2-thiazol-2-yl-ethyl)-(S)-carbamic acid tert-butyl ester

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Chemical Property of (1-{3-[5-(3,4-dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]-propylcarbamoyl}-2-thiazol-2-yl-ethyl)-(S)-carbamic acid tert-butyl ester

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Technology Process of (1-{3-[5-(3,4-dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]-propylcarbamoyl}-2-thiazol-2-yl-ethyl)-(S)-carbamic acid tert-butyl ester

There total 12 articles about (1-{3-[5-(3,4-dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]-propylcarbamoyl}-2-thiazol-2-yl-ethyl)-(S)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312304-12-3
2-(3-amino-propyl)-1H-indole-5-carboxylic acid (3,4-dimethoxy-phenyl)-amide

: 879502-02-0
Boc-Thi-OH

: 1312304-13-4
(1-{3-[5-(3,4-dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]-propylcarbamoyl}-2-thiazol-2-yl-ethyl)-(S)-carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 19718-49-1
4-amino-3-iodobenzoic acid methyl ester

: 1312304-13-4
(1-{3-[5-(3,4-dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]-propylcarbamoyl}-2-thiazol-2-yl-ethyl)-(S)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: water; lithium hydroxide / methanol / 20 h / Inert atmosphere; Reflux

2: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 24 h / 20 °C

3: diethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 24 h / 20 °C

4: Pd(PhCN)2Cl₂ / N,N-dimethyl-formamide / 24 h / 80 °C

5: hydrogenchloride / dichloromethane; diethyl ether / 2 h

6: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 24 h / 20 °C

With hydrogenchloride; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; lithium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd(PhCN)2Cl₂; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 6097-07-0
N-(pent-4-ynyl)phthalimide

: 1312304-13-4
(1-{3-[5-(3,4-dimethoxy-phenylcarbamoyl)-1H-indol-2-yl]-propylcarbamoyl}-2-thiazol-2-yl-ethyl)-(S)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine / ethanol; water / 24 h / 20 °C

1.2: 0.5 h / 20 °C / pH 3

1.3: 0.25 h / 20 °C

2.1: triethylamine / dichloromethane / 20 °C / Ice/water bath

3.1: diethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 24 h / 20 °C

4.1: Pd(PhCN)2Cl₂ / N,N-dimethyl-formamide / 24 h / 80 °C

5.1: hydrogenchloride / dichloromethane; diethyl ether / 2 h

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 24 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; hydrazine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd(PhCN)2Cl₂; In diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;