19718-49-1

Basic information

• Product Name: Methyl 4-amino-3-iodobenzoate
• Synonyms: METHYL 4-AMINO-3-IODOBENZOATE;Methyl 4-amino-3-iodobenzozte;2-Iodo-4-carboMethoxyaniline;Methyl 4-aMino-3-iodobenzoate;Methyl 4-aMino-3-iodobenzoate 95% (GC);Methyle4-amino-3-iodobenzoate
• CAS NO: 19718-49-1
• Molecular Formula: C₈H₈INO₂
• Molecular Weight: 277.06
• Product Categories: Aromatic Esters;API intermediates;C8 to C9;Carbonyl Compounds;Esters;Building Blocks;C8 to C9;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 19718-49-1.mol
• Article Data: 26

Chemical Properties

• Melting Point: 86-91 °C(lit.)
• Boiling Point: 369.6°C at 760 mmHg
• Flash Point: 177.3°C
• Appearance: Beige/Crystalline Powder
• Density: 1.826g/cm³
• Vapor Pressure: 1.17E-05mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 0.41±0.10(Predicted)
• CAS DataBase Reference: Methyl 4-amino-3-iodobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-amino-3-iodobenzoate(19718-49-1)
• EPA Substance Registry System: Methyl 4-amino-3-iodobenzoate(19718-49-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 19718-49-1(Hazardous Substances Data)

Usage

General Description

Methyl 4-amino-3-iodobenzoate is a chemical compound with the molecular formula C8H8INO2. It is commonly used in the pharmaceutical industry as an intermediate in the synthesis of organic compounds. Methyl 4-amino-3-iodobenzoate is a derivative of benzoic acid and contains an amino group and an iodine atom. Methyl 4-amino-3-iodobenzoate is known for its reactivity and is often used as a building block in the production of various pharmaceutical products, such as analgesics and anti-inflammatory drugs. Additionally, it has applications in organic synthesis, research and development, and in the manufacturing of specialty chemicals. Due to its potentially hazardous nature, it is important to handle and store this compound with caution, following appropriate safety protocols.

InChI:InChI=1/C8H8INO2/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4H,10H2,1H3

Upstream product

• 67-56-1 methanol 
• 2122-63-6 4-amino-3-iodobenzoic acid 
• 99512-09-1 3-amino-4-nitrobenzoic acid methyl ester 
• 150-13-0 4-amino-benzoic acid 
• 619-45-4 4-methoxycarbonyl aniline 

Downstream Products

• 212063-21-3 methyl 4-{[(benzyloxy)carbonyl]amino}-3-iodobenzoate 
• 444166-93-2 methyl 3-iodo-4-acrylamidobenzoate 
• 874764-42-8 methyl 3-iodo-4-(methylselenyl)benzoate 
• 524916-42-5 methyl 4-amino-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 619-45-4 4-methoxycarbonyl aniline 
• 910480-67-0 methyl 4-cyclohexylamino-3-iodobenzoate 
• 111714-47-7 3-acetyl-4-aminobenzoic acid methyl ester 
• 690664-23-4 4-amino-3-[(1E)-3-methoxy-3-oxo-1-propenyl]-benzoic acid methyl ester 
• 1160787-01-8 methyl 2-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylate 
• 1213706-18-3 methyl 2-(phenylamino)benzo[d]thiazole-6-carboxylate 
• 634616-75-4 C₁₂H₁₃NO₄ 
• 1333392-06-5 methyl-4-azido-3-(hept-1-yn-1-yl)benzoate 
• 1333392-22-5 dimethyl-2-(5-(2-azido-5-(methoxycarbonyl)phenyl)pent-4-yn-1-yl)malonate 
• 1333392-17-8 dimethyl 2-(5-(2-amino-5-(methoxycarbonyl)phenyl)pent-4-yn-1-yl)malonate 

Relevant articles and documents

Living Cyclocopolymerization through Alternating Insertion of Isocyanide and Allene via Controlling the Reactivity of the Propagation Species: Detailed Mechanistic Investigation

Living cyclocopolymerization through the alternating insertion of an isocyanide and allene into palladium-carbon bond was developed based on the controlling the reactivity of the propagation species using bidentate ligands. We revealed that the rate of the presented cyclocopolymerization was depended on the ligands of Pd-initiator. When the palladium-methyl complexes having appropriate cis-chelating ligand, such as 1,3-bis(diphenylphosphino)propane (dppp), were used as initiator, the cyclocopolymerization of bifunctional aryl isocyanides (1) that contain both isocyano and allenyl moieties polymerized to afford poly(quinolylene-2,3-methylene)s with controlled molecular weight and narrow molecular weight distributions. The resulting polymer was characterized by 1H and 13C NMR analyses, which clearly showed that the terminal moiety of the polymer formed well-defined organopalladium complex as the resting state for the polymerization, which could undergo further polymerization; not only cyclocopolymerization with 1 but also homopolymerization of simple aryl isocyanide. In the analysis of the cyclocopolymerization mechanism, we conclusively demonstrated that the insertion reaction of isocyanide is the rate-determination step in the cyclocopolymerization, which proceeds via a five-coordinate intermediate with a geometrical change. The cis-chelating ligand controls the site interchange reaction, which dominates the reactivity of propagation species.

SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME

Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

Synthesis of carbazoles based on gold-copper tandem catalysis

An efficient synthetic method for carbazoles has been developed employing diazo anilinoalkynes as substrates. Sequential activation of the orthogonal functional groups embedded in diazo anilinoalkyne substrates by tandem gold-copper catalysis leads to the formation of highly substituted carbazoles. Substrate scope reveals a broad tolerability toward the substitution on aryl groups.