3-<2-Methyl-3-methoxy-5-<-O-methyl-(S)-glycinyl>oxy>-N-(tert-butoxycarbonyl)-(R)-4-methoxyphenylglycine pentafluorophenyl ester

Base Information

Chemical Name:3-<2-Methyl-3-methoxy-5-<-O-methyl-(S)-glycinyl>oxy>-N-(tert-butoxycarbonyl)-(R)-4-methoxyphenylglycine pentafluorophenyl ester
CAS No.:159579-78-9
Molecular Formula:C₄₈H₄₆F₅N₃O₁₂
Molecular Weight:951.898
Hs Code.:

3-<2-Methyl-3-methoxy-5-<<N-(benzyloxycarbonyl)-(R)-phenylalanyl>-O-methyl-(S)-glycinyl>oxy>-N-(tert-butoxycarbonyl)-(R)-4-methoxyphenylglycine pentafluorophenyl ester

Synonyms:3-<2-Methyl-3-methoxy-5-<-O-methyl-(S)-glycinyl>oxy>-N-(tert-butoxycarbonyl)-(R)-4-methoxyphenylglycine pentafluorophenyl ester

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Chemical Property of 3-<2-Methyl-3-methoxy-5-<-O-methyl-(S)-glycinyl>oxy>-N-(tert-butoxycarbonyl)-(R)-4-methoxyphenylglycine pentafluorophenyl ester

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Technology Process of 3-<2-Methyl-3-methoxy-5-<-O-methyl-(S)-glycinyl>oxy>-N-(tert-butoxycarbonyl)-(R)-4-methoxyphenylglycine pentafluorophenyl ester

There total 9 articles about 3-<2-Methyl-3-methoxy-5-<-O-methyl-(S)-glycinyl>oxy>-N-(tert-butoxycarbonyl)-(R)-4-methoxyphenylglycine pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 159579-77-8
(R)-(3-{5-[(S)-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-methoxycarbonyl-methyl]-3-methoxy-2-methyl-phenoxy}-4-methoxy-phenyl)-tert-butoxycarbonylamino-acetic acid

: 159579-78-9
3-<2-Methyl-3-methoxy-5-<-O-methyl-(S)-glycinyl>oxy>-N-(tert-butoxycarbonyl)-(R)-4-methoxyphenylglycine pentafluorophenyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; 1.) 0 deg C, 2 h, 2.) room temp., overnight;
DOI:10.1021/jo00088a010

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 159579-78-9
3-<2-Methyl-3-methoxy-5-<-O-methyl-(S)-glycinyl>oxy>-N-(tert-butoxycarbonyl)-(R)-4-methoxyphenylglycine pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: EDC, HOBT / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) room temp., 15 min

2: MgBr₂*Et₂O / CH₂Cl₂ / 36 h / Ambient temperature

3: 60 percent / DCC / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) room temp., overnight

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; dicyclohexyl-carbodiimide; magnesium bromide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00088a010

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 159579-78-9
3-<2-Methyl-3-methoxy-5-<-O-methyl-(S)-glycinyl>oxy>-N-(tert-butoxycarbonyl)-(R)-4-methoxyphenylglycine pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 10percent Pd-C / tetrahydrofuran / 38 h

3: EDC, HOBT / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) room temp., 15 min

4: MgBr₂*Et₂O / CH₂Cl₂ / 36 h / Ambient temperature

5: 60 percent / DCC / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) room temp., overnight

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; dicyclohexyl-carbodiimide; magnesium bromide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00088a010