(R)-2-(3-tert-butyldimethylsilyloxy-4-methoxy)phenyl-1-(3,4,5-trimethoxyphenyl)ethanol

Base Information

Chemical Name:(R)-2-(3-tert-butyldimethylsilyloxy-4-methoxy)phenyl-1-(3,4,5-trimethoxyphenyl)ethanol
CAS No.:97315-21-4
Molecular Formula:C₂₄H₃₆O₆Si
Molecular Weight:448.632
Hs Code.:

Synonyms:(R)-2-(3-tert-butyldimethylsilyloxy-4-methoxy)phenyl-1-(3,4,5-trimethoxyphenyl)ethanol

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Chemical Property of (R)-2-(3-tert-butyldimethylsilyloxy-4-methoxy)phenyl-1-(3,4,5-trimethoxyphenyl)ethanol

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Technology Process of (R)-2-(3-tert-butyldimethylsilyloxy-4-methoxy)phenyl-1-(3,4,5-trimethoxyphenyl)ethanol

There total 15 articles about (R)-2-(3-tert-butyldimethylsilyloxy-4-methoxy)phenyl-1-(3,4,5-trimethoxyphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1439841-37-8
5,5-dimethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborinane

: 3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl trifluoromethanesulfonate

: 917-57-7
vinyllithium

: 97315-21-4
(R)-2-(3-tert-butyldimethylsilyloxy-4-methoxy)phenyl-1-(3,4,5-trimethoxyphenyl)ethanol

Guidance literature:: 5,5-dimethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborinane; 3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl trifluoromethanesulfonate; vinyllithium; With (SP, S'P)-1,1'-bis [bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2,2'-bis [(R)-α-(dimethylamino)benzyl]ferrocene; palladium diacetate; In tetrahydrofuran; at 60 ℃; for 14h;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; enantioselective reaction;
DOI:10.1126/science.aad6080

Reference yield: 24.0%

: 97315-17-8
5-<(tert-butyldimethylsilyl)oxy>-(+/-)-combretastatin

: 97315-21-4
5-<(tert-butyldimethylsilyl)oxy>-(-)-combretastatin

Guidance literature:: In hexane; isopropyl alcohol;
DOI:10.1021/jo00218a032

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 97315-21-4
(R)-2-(3-tert-butyldimethylsilyloxy-4-methoxy)phenyl-1-(3,4,5-trimethoxyphenyl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / imidazole / dimethylformamide / 16 h / Ambient temperature

2: 1.) BuLi / 1.) THF, pentane, -78 deg C, 1 h, 2.) THF, pentane, from -78 deg C to RT, 3 h

With 1H-imidazole; n-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1016/0957-4166(96)00115-2