ethyl 7R-t-butyldimethylsilyloxy-7-phenyl-5S,6S-O-isopropylidene-4S-methoxymethyl-hepten-2Z-oate

Base Information

• Chemical Name: ethyl 7R-t-butyldimethylsilyloxy-7-phenyl-5S,6S-O-isopropylidene-4S-methoxymethyl-hepten-2Z-oate
• CAS No.: 338385-78-7
• Molecular Formula: C₂₆H₄₂O₇Si
• Molecular Weight: 494.701

Synonyms:ethyl 7R-t-butyldimethylsilyloxy-7-phenyl-5S,6S-O-isopropylidene-4S-methoxymethyl-hepten-2Z-oate

Chemical Property of ethyl 7R-t-butyldimethylsilyloxy-7-phenyl-5S,6S-O-isopropylidene-4S-methoxymethyl-hepten-2Z-oate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 7R-t-butyldimethylsilyloxy-7-phenyl-5S,6S-O-isopropylidene-4S-methoxymethyl-hepten-2Z-oate

There total 8 articles about ethyl 7R-t-butyldimethylsilyloxy-7-phenyl-5S,6S-O-isopropylidene-4S-methoxymethyl-hepten-2Z-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl 7R-t-butyldimethylsilyloxy-7-phenyl-5S,6S-O-isopropylidene-4S-methoxymethyl-heptyn-2-oate → ethyl 7R-t-butyldimethylsilyloxy-7-phenyl-5S,6S-O-isopropylidene-4S-methoxymethyl-hepten-2Z-oate (338385-78-7)

Guidance literature:

With quinoline; hydrogen; Lindlar's catalyst; In ethyl acetate; at 30 ℃; for 72h; under 760 Torr;

DOI:10.1016/S0040-4020(01)00050-3

Reference yield:

phenylmagnesium bromide → ethyl 7R-t-butyldimethylsilyloxy-7-phenyl-5S,6S-O-isopropylidene-4S-methoxymethyl-hepten-2Z-oate (338385-78-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 35 percent / tetrahydrofuran / -78 - 20 °C

2.1: 85.4 percent / imidazole / dimethylformamide / 24 h / 20 °C

3.1: 97 percent / H₂ / Pd/C / ethyl acetate / 6 h / 45 °C / 760 Torr

4.1: Dess-Martin periodinane / CH₂Cl₂ / 1 h

5.1: lithium diisopropylamide / tetrahydrofuran / -78 - 1 °C

5.2: 79 percent / tetrahydrofuran / 12 h / -78 °C

6.1: 73 percent / diisopropylethylamine / CH₂Cl₂ / 24 h / 40 °C

7.1: 91 percent / H₂; quinoline / Lindlar catalyst / ethyl acetate / 72 h / 30 °C / 760 Torr

With 1H-imidazole; quinoline; hydrogen; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium on activated charcoal; Lindlar's catalyst; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1.1: Grignard reaction / 4.1: Dess-Martin oxidation;

DOI:10.1016/S0040-4020(01)00050-3

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → ethyl 7R-t-butyldimethylsilyloxy-7-phenyl-5S,6S-O-isopropylidene-4S-methoxymethyl-hepten-2Z-oate (338385-78-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 85.4 percent / imidazole / dimethylformamide / 24 h / 20 °C

2.1: 97 percent / H₂ / Pd/C / ethyl acetate / 6 h / 45 °C / 760 Torr

3.1: Dess-Martin periodinane / CH₂Cl₂ / 1 h

4.1: lithium diisopropylamide / tetrahydrofuran / -78 - 1 °C

4.2: 79 percent / tetrahydrofuran / 12 h / -78 °C

5.1: 73 percent / diisopropylethylamine / CH₂Cl₂ / 24 h / 40 °C

6.1: 91 percent / H₂; quinoline / Lindlar catalyst / ethyl acetate / 72 h / 30 °C / 760 Torr

With 1H-imidazole; quinoline; hydrogen; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium on activated charcoal; Lindlar's catalyst; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3.1: Dess-Martin oxidation;

DOI:10.1016/S0040-4020(01)00050-3

upstream raw materials:

tert-butyldimethylsilyl chloride

(4R)-4-t-butyldimethylsilyloxy-4-phenyl-2S,3S-O-isopropylidene-butanol

(4S,5S)-5-[(S)-(tert-Butyl-dimethyl-silanyloxy)-phenyl-methyl]-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde

(4R)-4-hydroxy-4-phenyl-2S,3S-O-isopropylidene-butyl benzyl ether

Downstream raw materials:

(+)-goniofufurone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 338385-78-7 ethyl 7R-t-butyldimethylsilyloxy-7-phenyl-5S,6S-O-isopropylidene-4S-methoxymethyl-hepten-2Z-oate

Send

Send

Metric Ton KG G Pound L ML

Send

Send