4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-hydroxymethyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-hydroxymethyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine
CAS No.:443642-61-3
Molecular Formula:C₂₆H₂₂Cl₅N₃O₅
Molecular Weight:633.743
Hs Code.:

Synonyms:4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-hydroxymethyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Property of 4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-hydroxymethyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

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Technology Process of 4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-hydroxymethyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

There total 5 articles about 4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-hydroxymethyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 443642-58-8
4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-vinyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

: 443642-61-3
4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-hydroxymethyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: 4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-vinyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine; With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In 1,3-dioxane; water; for 14h;

In dichloromethane; for 12h;

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 4h;

Reference yield:

: 443643-38-7
3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-vinyl-1-O-methyl-α-D-ribofuranose

: 443642-61-3
4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-hydroxymethyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen bromide; acetic acid / dichloromethane / 4 h / -20 - 0 °C

1.2: 24 h / -20 - 20 °C

2.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / 1,4-dioxane; water / 14 h / Darkness

2.2: 12 h

2.3: 4 h / 20 °C / Cooling with ice

With osmium(VIII) oxide; hydrogen bromide; acetic acid; 4-methylmorpholine N-oxide; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 168427-36-9
2-O-acetyl-3,5-bis-O-(2,4-dichlorophenylmethyl)-1-O-methyl-α-D-ribofuranose

: 443642-61-3
4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-hydroxymethyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol; potassium carbonate / 0.75 h / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 73 h / 0 - 20 °C / Inert atmosphere

3.1: cerium(III) chloride heptahydrate / tetrahydrofuran / 6 h / -78 °C / Inert atmosphere

3.2: 4 h / -78 °C

4.1: hydrogen bromide; acetic acid / dichloromethane / 4 h / -20 - 0 °C

4.2: 24 h / -20 - 20 °C

5.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / 1,4-dioxane; water / 14 h / Darkness

5.2: 12 h

5.3: 4 h / 20 °C / Cooling with ice

With methanol; osmium(VIII) oxide; cerium(III) chloride heptahydrate; hydrogen bromide; potassium carbonate; Dess-Martin periodane; acetic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;