4-hydroxy-N,N,N-trimethyl-9-phenyl-7-<(2-hexadecylphenoxy)methyl>-3,5,8-trioxa-4-phosphanonan-1-aminium 4-oxide, hydroxide, inner salt

Base Information

• Chemical Name: 4-hydroxy-N,N,N-trimethyl-9-phenyl-7-<(2-hexadecylphenoxy)methyl>-3,5,8-trioxa-4-phosphanonan-1-aminium 4-oxide, hydroxide, inner salt
• CAS No.: 90857-91-3
• Molecular Formula: C₃₇H₆₂NO₆P
• Molecular Weight: 647.876
• Mol file: 90857-91-3.mol

Synonyms:4-hydroxy-N,N,N-trimethyl-9-phenyl-7-<(2-hexadecylphenoxy)methyl>-3,5,8-trioxa-4-phosphanonan-1-aminium 4-oxide, hydroxide, inner salt

Chemical Property of 4-hydroxy-N,N,N-trimethyl-9-phenyl-7-<(2-hexadecylphenoxy)methyl>-3,5,8-trioxa-4-phosphanonan-1-aminium 4-oxide, hydroxide, inner salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-N,N,N-trimethyl-9-phenyl-7-<(2-hexadecylphenoxy)methyl>-3,5,8-trioxa-4-phosphanonan-1-aminium 4-oxide, hydroxide, inner salt

There total 9 articles about 4-hydroxy-N,N,N-trimethyl-9-phenyl-7-<(2-hexadecylphenoxy)methyl>-3,5,8-trioxa-4-phosphanonan-1-aminium 4-oxide, hydroxide, inner salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-iodohexadecane (544-77-4) → 4-hydroxy-N,N,N-trimethyl-9-phenyl-7-<(2-hexadecylphenoxy)methyl>-3,5,8-trioxa-4-phosphanonan-1-aminium 4-oxide, hydroxide, inner salt (90857-91-3)

Guidance literature:

Multi-step reaction with 9 steps

1: 1.) Mg, 2.) dilithium tetrachlorocopper(II) / 1.) THF, reflux, 2 h, 2.) a) THF, reflux, 2 h, b) THF, RT, 16 h

2: 96 percent / BBr₃ / CH₂Cl₂ / 3 h / Ambient temperature

3: 1.) NaH / 1.) DMF, reflux, 2 h, 2.) DMF, reflux, 24 h

4: 61 percent / 1N aq. HCl / methanol / 3 h / Heating

5: 97 percent / pyridine / 48 h / Ambient temperature

6: 73 percent / NaH / dimethylformamide / 3 h / Ambient temperature

7: 33 percent / p-TsOH / methanol; tetrahydrofuran / 24 h / Ambient temperature

8: 1.) Et₃N, 2.) 0.5 M aq. AcONa / 1.) CCl₄, 2 h, 2.) THF

9: 1.) water, DMF, 2.) silver carbonate / 1.) chloroform, 2-propanol, 65 deg C, 5 h, 2.) ethanol, water, RT, 1 h

With pyridine; hydrogenchloride; dilithium tetrachlorocuprate; water; sodium acetate; boron tribromide; sodium hydride; toluene-4-sulfonic acid; magnesium; triethylamine; N,N-dimethyl-formamide; silver carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00375a016

Reference yield:

2-bromoanisole (578-57-4) → 4-hydroxy-N,N,N-trimethyl-9-phenyl-7-<(2-hexadecylphenoxy)methyl>-3,5,8-trioxa-4-phosphanonan-1-aminium 4-oxide, hydroxide, inner salt (90857-91-3)

Guidance literature:

Multi-step reaction with 9 steps

1: 1.) Mg, 2.) dilithium tetrachlorocopper(II) / 1.) THF, reflux, 2 h, 2.) a) THF, reflux, 2 h, b) THF, RT, 16 h

2: 96 percent / BBr₃ / CH₂Cl₂ / 3 h / Ambient temperature

3: 1.) NaH / 1.) DMF, reflux, 2 h, 2.) DMF, reflux, 24 h

4: 61 percent / 1N aq. HCl / methanol / 3 h / Heating

5: 97 percent / pyridine / 48 h / Ambient temperature

6: 73 percent / NaH / dimethylformamide / 3 h / Ambient temperature

7: 33 percent / p-TsOH / methanol; tetrahydrofuran / 24 h / Ambient temperature

8: 1.) Et₃N, 2.) 0.5 M aq. AcONa / 1.) CCl₄, 2 h, 2.) THF

9: 1.) water, DMF, 2.) silver carbonate / 1.) chloroform, 2-propanol, 65 deg C, 5 h, 2.) ethanol, water, RT, 1 h

With pyridine; hydrogenchloride; dilithium tetrachlorocuprate; water; sodium acetate; boron tribromide; sodium hydride; toluene-4-sulfonic acid; magnesium; triethylamine; N,N-dimethyl-formamide; silver carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00375a016

Reference yield:

mono-hexadecylphenol (25401-86-9) → 4-hydroxy-N,N,N-trimethyl-9-phenyl-7-<(2-hexadecylphenoxy)methyl>-3,5,8-trioxa-4-phosphanonan-1-aminium 4-oxide, hydroxide, inner salt (90857-91-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) NaH / 1.) DMF, reflux, 2 h, 2.) DMF, reflux, 24 h

2: 61 percent / 1N aq. HCl / methanol / 3 h / Heating

3: 97 percent / pyridine / 48 h / Ambient temperature

4: 73 percent / NaH / dimethylformamide / 3 h / Ambient temperature

5: 33 percent / p-TsOH / methanol; tetrahydrofuran / 24 h / Ambient temperature

6: 1.) Et₃N, 2.) 0.5 M aq. AcONa / 1.) CCl₄, 2 h, 2.) THF

7: 1.) water, DMF, 2.) silver carbonate / 1.) chloroform, 2-propanol, 65 deg C, 5 h, 2.) ethanol, water, RT, 1 h

With pyridine; hydrogenchloride; water; sodium acetate; sodium hydride; toluene-4-sulfonic acid; triethylamine; N,N-dimethyl-formamide; silver carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00375a016

upstream raw materials:

1-iodohexadecane

2-bromoanisole

mono-hexadecylphenol

3-(2-hexadecylphenoxy)-1,2-propanediol

Downstream raw materials:

4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(2-hexadecylphenoxy)methyl]-3,5,8-trioxa-4-phosphadecan-1-aminium 4-oxide, hydroxide, inner salt

2-<phosphinyl>oxy>-N,N,N-trimethylethanaminium, hydroxide, inner salt

Refernces