25401-86-9Relevant academic research and scientific papers
Alkylated phenol series in lacustrine black shales from the Noerdlinger Ries, southern Germany
Barakat, Assem O.,Baumgart, Susan,Brocks, Peter,Scholz-Boettcher, Barbara M.,Rullkoetter, Juergen
, p. 987 - 994 (2012/11/06)
Several series of alkylated phenols were detected for the first time in the extractable bitumens of organic matter-rich sediments from the Noerdlinger Ries (southern Germany). Most abundant and significant constituents comprise those with n-octadecyl, n-eicosanyl, phytanyl, and iso-pentadecyl and anteiso-pentadecyl substituents. The structures of these compounds are suggested from mass spectrometric and retention time data and coinjection with synthetic standards. Diagenetic alteration of phenolic algal lipids is suggested as a possible way to the formation of these compounds in the Noerdlinger Ries sediments. Copyright
Synthesis of some new thiazolopyrane and thiazolopyranopyrimidine derivatives bearing a sulfonamide moiety for evaluation as anticancer and radiosensitizing agents
El Ella, Dalal A. Abou,Ghorab, Mostafa M.,Heiba, Helmy I.,Soliman, Aiten M.
, p. 2395 - 2407 (2012/11/06)
A new series of thiazolopyrane 5a-d, 11-13 and thiazolopyranopyrimidine 6-10, 7b, 8b, and 14 derivatives bearing a sulfonamide moiety were designed and synthesized. The molecular design was performed using molecular operating environment software to predict the binding mode of the proposed compounds on hCAII. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against human liver cancer cell line in which hCAII is overexpressed. Compounds 8b and 14 showed higher activities compared with doxorubicin as a positive control. The radiosensitizing ability of the promising compounds 3, 7a, 8b, 12, and 14 was studied which showed an increase in the cell killing effect of γ-radiation after combination with them. Springer Science+Business Media, LLC 2011.
Mannich reaction products derived from alkenyl succinic acid anhydride, a polyamine and sulphur linked alkylphenols and their use as lubricants
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, (2008/06/13)
Disclosed is a mannich reaction product which is obtainable by reacting an alkenyl succinic acid or an alkenyl succinic anhydride, a polyamine, an aldehyde and a sulfurized alkylphenol represented by the general formula (I). wherein R2 indicates an alkyl group having 4 to 25 carbon atoms, m indicates an integer of 1 to 8, x indicates 1 or 2, and z indicates an integer of 1 to 9. Useful as a detergent-dispersant which has excellent stability at high temperatures and has an oxidation stability, a detergent-dispersant containing the same, a process of producing it, and fuel oil and lubricating oil compositions comprising it.
Total synthesis of (±)-chondrillin, (±)-plakorin, and related peroxy ketals. development of a general route to 3,6-dihydro-1,2-dioxin-3-ols
Snider, Barry B.,Shi, Zhongping
, p. 1790 - 1800 (2007/10/02)
Seven-step syntheses of the antitumor cyclic peroxy ketals la, 2a, chondrillin (Ib), and plakorin (2b) from (methoxymethoxy)benzene (8) have been achieved in 26-28% overall yields. The key step is the photooxygenation of enone 4 with a sun lamp using rose bengal lactone or CuSO4 as a sensitizer which gives a mixture of peroxy hemiketals 15 and 16 in 75-85% yields. Acetal formation in acidic methanol completes the syntheses of 1 and 2. The mechanism of photooxygenation was ascertained using 3-nonen-2-one (22) as a model for 4. Irradiation converts 22 to the cis-enone 23 which undergoes photoenolization to give 24. Dienol 24 undergoes a sensitized reaction with oxygen to give 29 and 30. The detailed mechanism of this last step is not known, although singlet oxygen is probably not involved. This reaction is general for any enone or enal which can undergo photoenolization to give a dienol. Peroxy hemiketals 33a, 41, and 43-46 were prepared in 30-80% yields. Peroxy ketals can be used for the synthesis of furans, diones, and pyridazines.
Overbased sulfurized alkaline earth metal phenates and process for preparing same
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, (2008/06/13)
Overbased sulfurized alkaline earth metal phenates which are oil soluble, excellent in detergency dispersancy and have high base value, and an effective process for production of said overbased sulfurized alkaline earth metal phenates under conditions providing less sludge and less raw material recovery, and further a lubricating oil additives containing said overbased sulfurized alkaline earth metal phenates as a main ingredient and a lubricating oil composition which comprises said lubricating oil additive compounded in a lubricating oil are disclosed. Since the resulting overbased sulfurized alkaline earth metal phenates have high base value and excellent oil-solubility, they can be effectively utilized as lubricating oil additives.
Phosphocholine derivatives having antihypertensive action
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, (2008/06/13)
Phosphocholine derivatives and compositions are described which are useful as hypotensive agents and in the treatment of hypertension in warm-blooded animals.
Analogues of platelet activating factor (PAF). I. Some modifications of the alkoxy chain
Wissner,Sum,Schaub,Kohler,Goldstein
, p. 1174 - 1181 (2007/10/02)
Analogues of platelet activating factor (PAF) in which the ether oxygen has been removed and in which the alkoxy chain at C1 has been replaced with a o-, p-, or m-alkylphenoxy group (30, 31, and 35, respectively) have been prepared. Compound 6 shows reduced platelet aggregation and hypotensive activity in comparison with C16 and C18 PAF. The results obtained for compounds 30, 31, and 35 indicate that the hypotensive and platelet aggregating responses are sensitive to structural modification of the ether chain. The ortho analogue 30 shows no platelet aggregating activity and only a weak hypotensive response. The para analogue 31 exhibits a moderate decrease in activity in both assays. The meta analogue 35 is the most active of the three.
