(S)-2-(2-hydroxy-5-methylphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester trifluoroacetate

Base Information

• Chemical Name: (S)-2-(2-hydroxy-5-methylphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester trifluoroacetate
• CAS No.: 1334386-29-6
• Molecular Formula: C₂HF₃O₂*C₁₄H₁₈N₂O₃S
• Molecular Weight: 408.398
• Mol file: 1334386-29-6.mol

Synonyms:(S)-2-(2-hydroxy-5-methylphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester trifluoroacetate

Chemical Property of (S)-2-(2-hydroxy-5-methylphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(2-hydroxy-5-methylphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester trifluoroacetate

There total 3 articles about (S)-2-(2-hydroxy-5-methylphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-chloro-5-methyl-1,3-benzoxazole (3770-60-3) + D-penicillamine methyl ester hydrochloride (34297-27-3) + trifluoroacetic acid (76-05-1) → (S)-2-(2-hydroxy-5-methylphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester trifluoroacetate (1334386-29-6)

Guidance literature:

2-chloro-5-methyl-1,3-benzoxazole; D-penicillamine methyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile; HPLC;

Reference yield:

3-amino-4-hydroxytoluene (95-84-1) → (S)-2-(2-hydroxy-5-methylphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester trifluoroacetate (1334386-29-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol / Reflux

1.2: pH 5

2.1: thionyl chloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3.2: HPLC

With thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

5-methylbenzo[d]oxazole-2-thiol (22876-22-8) → (S)-2-(2-hydroxy-5-methylphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester trifluoroacetate (1334386-29-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2.2: HPLC

With thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In N,N-dimethyl-formamide;

upstream raw materials:

2-chloro-5-methyl-1,3-benzoxazole

D-penicillamine methyl ester hydrochloride

trifluoroacetic acid

3-amino-4-hydroxytoluene