Technology Process of 3-cyano-5-ethynyl-4-methoxybenzoyl chloride
There total 9 articles about 3-cyano-5-ethynyl-4-methoxybenzoyl chloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride;
N,N-dimethyl-formamide;
In
toluene;
at 20 ℃;
for 1.5h;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 20 °C
2: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1.5 h / 20 °C / Cooling with ice
With
oxalyl dichloride; lithium hydroxide monohydrate; water;
N,N-dimethyl-formamide;
In
tetrahydrofuran; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N-iodo-succinimide; trifluorormethanesulfonic acid / methanol; chloroform / 1 h / 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C
3: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 1 h / 20 °C
4: water; sodium hydroxide / tetrahydrofuran / 0.17 h / 20 °C
5: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 20 °C
6: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1.5 h / 20 °C / Cooling with ice
With
N-iodo-succinimide; oxalyl dichloride; lithium hydroxide monohydrate; trifluorormethanesulfonic acid; water; potassium carbonate; sodium hydroxide;
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; toluene;
