(tert-butoxycarbonyl)-L-valine-L-(benzyl)-meta-tyrosine carboxylic acid ethyl ester

Base Information

Chemical Name:(tert-butoxycarbonyl)-L-valine-L-(benzyl)-meta-tyrosine carboxylic acid ethyl ester
CAS No.:247186-20-5
Molecular Formula:C₂₈H₃₈N₂O₆
Molecular Weight:498.62
Hs Code.:

Synonyms:(tert-butoxycarbonyl)-L-valine-L-(benzyl)-meta-tyrosine carboxylic acid ethyl ester

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Chemical Property of (tert-butoxycarbonyl)-L-valine-L-(benzyl)-meta-tyrosine carboxylic acid ethyl ester

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Technology Process of (tert-butoxycarbonyl)-L-valine-L-(benzyl)-meta-tyrosine carboxylic acid ethyl ester

There total 5 articles about (tert-butoxycarbonyl)-L-valine-L-(benzyl)-meta-tyrosine carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 13734-41-3
t-Boc-L-valine

: (S)-2-Amino-3-(3-benzyloxy-phenyl)-propionic acid ethyl ester

: 247186-20-5
(tert-butoxycarbonyl)-L-valine-L-(benzyl)-meta-tyrosine carboxylic acid ethyl ester

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran;
DOI:10.1002/(SICI)1521-3773(19990816)38:16<2443::AID-ANIE2443>3.0.CO;2-B

Reference yield:

: 1700-31-8
3-benzyloxybenzyl bromide

: 247186-20-5
(tert-butoxycarbonyl)-L-valine-L-(benzyl)-meta-tyrosine carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: 62 percent / tetrahydrofuran; hexane / 1.5 h / -78 °C

2.1: 71 percent / aq. HCl / acetonitrile / 2 h / 20 °C

3.1: 8.85 g / tetrahydrofuran / -15 - 20 °C

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1021/ja021327y

Reference yield:

: 247186-19-2
(2S,5R)-2-(3-benzyloxybenzyl)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazine

: 247186-20-5
(tert-butoxycarbonyl)-L-valine-L-(benzyl)-meta-tyrosine carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / aq. HCl / acetonitrile / 2 h / 20 °C

2: 8.85 g / tetrahydrofuran / -15 - 20 °C

With hydrogenchloride; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ja021327y