(S)-3-(3-(benzyloxy)phenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)propanoic acid

Base Information

• Chemical Name: (S)-3-(3-(benzyloxy)phenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)propanoic acid
• CAS No.: 222556-20-9
• Molecular Formula: C₂₆H₃₄N₂O₆
• Molecular Weight: 470.566
• Mol file: 222556-20-9.mol

Synonyms:(S)-3-(3-(benzyloxy)phenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)propanoic acid

Chemical Property of (S)-3-(3-(benzyloxy)phenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(3-(benzyloxy)phenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)propanoic acid

There total 23 articles about (S)-3-(3-(benzyloxy)phenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(tert-butoxycarbonyl)-L-valine-L-(benzyl)-meta-tyrosine carboxylic acid ethyl ester (247186-20-5) → (S)-3-(3-(benzyloxy)phenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)propanoic acid (222556-20-9)

Guidance literature:

With lithium hydroxide; water; In tetrahydrofuran;

DOI:10.1002/(SICI)1521-3773(19990816)38:16<2443::AID-ANIE2443>3.0.CO;2-B

Reference yield: 87.0%

C27H36N2O6 → (S)-3-(3-(benzyloxy)phenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)propanoic acid (222556-20-9)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 0 - 20 ℃; for 3h;

DOI:10.1080/00397911.2014.947653

Reference yield: 77.0%

{(S)-1-[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-1-(3-benzyloxy-benzyl)-2-oxo-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid tert-butyl ester (222556-19-6) → (S)-3-(3-(benzyloxy)phenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)propanoic acid (222556-20-9)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃;

DOI:10.1016/S0040-4039(99)00212-9

upstream raw materials:

{(S)-1-[(S)-2-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-1-(3-benzyloxy-benzyl)-2-oxo-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid tert-butyl ester

(tert-butoxycarbonyl)-L-valine-L-(benzyl)-meta-tyrosine carboxylic acid ethyl ester

t-Boc-L-valine

3-benzyloxybenzyl bromide

Downstream raw materials:

(tert-butoxycarbonyl)-L-valine-L-(benzyl)-meta-tyrosine-hexahydropyridazine-3S-carboxylic acid 2,2,2-trichloroethyl ester

(tert-butoxycarbonyl)-L-valine-L-(tert-butyldimethylsilyl)-meta-tyrosine-hexahydropyridazine-3S-carboxylic acid 2,2,2-trichloroethyl ester

(13E,15E)-(3S,6S,21S)-3-[3-(tert-Butyl-dimethyl-silanyloxy)-benzyl]-6-isopropyl-19-oxa-1,4,7,25-tetraaza-bicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

hept-6-en-1-oyl-L-valine-L-(tert-butyldimethylsilyl)-meta-tyrosine-hexahydropyridazine-3S-carboxylic acid 2,2,2-trichloroethyl ester