benzyl 5-ethyl-1-(methoxycarbonylmethyl)-1H-2-indolecarboxylate

Base Information

• Chemical Name: benzyl 5-ethyl-1-(methoxycarbonylmethyl)-1H-2-indolecarboxylate
• CAS No.: 216169-30-1
• Molecular Formula: C₂₁H₂₁NO₄
• Molecular Weight: 351.402
• Mol file: 216169-30-1.mol

Synonyms:benzyl 5-ethyl-1-(methoxycarbonylmethyl)-1H-2-indolecarboxylate

Chemical Property of benzyl 5-ethyl-1-(methoxycarbonylmethyl)-1H-2-indolecarboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of benzyl 5-ethyl-1-(methoxycarbonylmethyl)-1H-2-indolecarboxylate

There total 2 articles about benzyl 5-ethyl-1-(methoxycarbonylmethyl)-1H-2-indolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzyl 5-ethyl-1H-2-indolecarboxylate (216169-27-6) + bromoacetic acid methyl ester (96-32-2) → benzyl 5-ethyl-1-(methoxycarbonylmethyl)-1H-2-indolecarboxylate (216169-30-1)

Guidance literature:

benzyl 5-ethyl-1H-2-indolecarboxylate; With sodium hydride; In DMF (N,N-dimethyl-formamide); oil; at 0 ℃; for 0.666667h;

bromoacetic acid methyl ester; In DMF (N,N-dimethyl-formamide); oil; at 20 ℃; for 2h;

Reference yield: 90.0%

5-ethyl-1H-indole-2-carboxylic acid (37033-93-5) + benzyl bromide (100-39-0) → benzyl 5-ethyl-1-(methoxycarbonylmethyl)-1H-2-indolecarboxylate (216169-30-1)

Guidance literature:

5-ethyl-1H-indole-2-carboxylic acid; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 0 ℃; for 0.666667h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

upstream raw materials:

5-ethyl-1H-indole-2-carboxylic acid

benzyl bromide

benzyl 5-ethyl-1H-2-indolecarboxylate

bromoacetic acid methyl ester