4'-tert-Butyl-2'-methoxymethoxy-biphenyl-4-carboxylic acid benzylamide

Base Information

• Chemical Name: 4'-tert-Butyl-2'-methoxymethoxy-biphenyl-4-carboxylic acid benzylamide
• CAS No.: 161398-85-2
• Molecular Formula: C₂₆H₂₉NO₃
• Molecular Weight: 403.521
• Mol file: 161398-85-2.mol

Synonyms:4'-tert-Butyl-2'-methoxymethoxy-biphenyl-4-carboxylic acid benzylamide

Chemical Property of 4'-tert-Butyl-2'-methoxymethoxy-biphenyl-4-carboxylic acid benzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-tert-Butyl-2'-methoxymethoxy-biphenyl-4-carboxylic acid benzylamide

There total 1 articles about 4'-tert-Butyl-2'-methoxymethoxy-biphenyl-4-carboxylic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-N-benzylbenzamide (80311-89-3) + 3-tert-butyl-1-(methoxymethoxy)benzene (161398-79-4) → 4'-tert-Butyl-2'-methoxymethoxy-biphenyl-4-carboxylic acid benzylamide (161398-85-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Trimethyl borate; N,N,N,N,-tetramethylethylenediamine; water; sodium carbonate; Yield given. Multistep reaction;

DOI:10.1021/jm00023a009

Reference yield: 41.0%

4'-tert-Butyl-2'-methoxymethoxy-biphenyl-4-carboxylic acid benzylamide (161398-85-2) → N-benzyl-4'-tert-butyl-2'-hydroxybiphenyl-4-carboxamide

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 70 ℃; for 3h;

DOI:10.1021/jm00023a009

upstream raw materials:

4-bromo-N-benzylbenzamide

3-tert-butyl-1-(methoxymethoxy)benzene