6-(2-cyano-3-methyl-phenylamino)-N-(4-fluoro-benzyl)-4-isopropyl-nicotinamide

Base Information

Chemical Name:6-(2-cyano-3-methyl-phenylamino)-N-(4-fluoro-benzyl)-4-isopropyl-nicotinamide
CAS No.:676993-36-5
Molecular Formula:C₂₄H₂₃FN₄O
Molecular Weight:402.471
Hs Code.:

Synonyms:6-(2-cyano-3-methyl-phenylamino)-N-(4-fluoro-benzyl)-4-isopropyl-nicotinamide

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Chemical Property of 6-(2-cyano-3-methyl-phenylamino)-N-(4-fluoro-benzyl)-4-isopropyl-nicotinamide

Chemical Property:

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Technology Process of 6-(2-cyano-3-methyl-phenylamino)-N-(4-fluoro-benzyl)-4-isopropyl-nicotinamide

There total 4 articles about 6-(2-cyano-3-methyl-phenylamino)-N-(4-fluoro-benzyl)-4-isopropyl-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 676993-20-7
6-chloro-N-(4-fluoro-benzyl)-4-isopropyl-nicotinamide

: 56043-01-7
2-amino-6-methylbenzonitrile

: 676993-36-5
6-(2-cyano-3-methyl-phenylamino)-N-(4-fluoro-benzyl)-4-isopropyl-nicotinamide

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; for 24h; Heating / reflux;

Reference yield:

: 676993-19-4
6-chloro-N-(4-fluoro-benzyl)-nicotinamide

: 676993-36-5
6-(2-cyano-3-methyl-phenylamino)-N-(4-fluoro-benzyl)-4-isopropyl-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 16.75 h / 0 - 20 °C

1.2: 0.5 h

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 24 h / Heating / reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 58757-38-3
6-Chloronicotinoyl chloride

: 676993-36-5
6-(2-cyano-3-methyl-phenylamino)-N-(4-fluoro-benzyl)-4-isopropyl-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2.1: tetrahydrofuran / 16.75 h / 0 - 20 °C

2.2: 0.5 h

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 24 h / Heating / reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; dichloromethane;